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3-Hydroxycoumarin

Name: 3-Hydroxycoumarin
Brand: TargetMol
SKU: T8002
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8002Cas No. 939-19-5

3-Hydroxycoumarin is a natural compound, and is human 15-LOX-1 inhibitors

3-Hydroxycoumarin

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Purity: 99.77%

Catalog No. T8002Cas No. 939-19-5

3-Hydroxycoumarin is a natural compound, and is human 15-LOX-1 inhibitors

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.77%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

3-Hydroxycoumarin AI Summary

3-Hydroxycoumarin exhibits a wide range of bioactivities. It induces NAD(P)H quinone reductase activity in Hepa 1c1c7 murine hepatoma cells at 1.5 μM, indicating antioxidative potential. It significantly inhibits xanthine oxidase (IC50 = 131,000 nM) and shows efficacy as an enzyme inhibitor against carbonic anhydrase isozymes, especially CA9 (Kinact = 0.508 μM), while moderately inhibiting CA1 and CA12, and weakly inhibiting CA2. It induces apoptosis in human U937 cells at 250 μM, displaying cytotoxicity (CC50 > 2,000,000 nM). Additionally, it inhibits aldose reductase 1 (IC50 = 62,000 nM), aldose reductase 2 (IC50 = 172,000 nM), and sorbitol dehydrogenase (IC50 = 106,000 nM). 3-Hydroxycoumarin shows activity against alpha-glucosidase (IC50 = 35,300 nM) but no inhibition of Beta-galactosidase at 400 μM. It also inhibits HPGD (potency = 17,782.8 nM) and demonstrates antifungal activity against Aspergillus species. It is a strong inhibitor of DAO enzymes with significant activity against native and mutant forms, and a low IC50 against DAAO (IC50 = 34.67 nM, Ki = 13 nM). Moreover, it inhibits sodium fluorescein uptake in OATP1B1- and OATP1B3-transfected CHO cells and remains highly stable in glucuronidation assays using mouse liver microsomes. In cancer studies, it shows cytotoxicity against various human cancer cell lines, including PANC1, SK-MEL3, and SK-MEL-28 cells, with varying IC50 values indicating potential anticancer activity. It also activates Nrf2 in HSC3-ARE9 cells, increasing luciferase expression and showing antioxidant activity (DPPH EC50 = 65,800 nM). Furthermore, it exhibits antiviral activity by inhibiting SARS-CoV-2 3CL-Pro protease (30.28% inhibition at 20 μM) and reducing virus-induced cytotoxicity in VERO-6 cells at 10 μM (inhibition rate = 0.03%) and inhibits human tyrosinase (Ki = 3400 nM). Overall, 3-Hydroxycoumarin demonstrates considerable potential across various biochemical and pharmacological applications, including antioxidative, enzyme inhibition, anticancer, antifungal, and antiviral activities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

3-Hydroxycoumarin is a natural compound, and is human 15-LOX-1 inhibitors

Chemical Properties

Molecular Weight	162.14
Formula	C₉H₆O₃
Cas No.	939-19-5
Smiles	Oc1cc2ccccc2oc1=O
Relative Density.	1.446 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (169.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.1675 mL	30.8375 mL	61.6751 mL	308.3755 mL
5 mM	1.2335 mL	6.1675 mL	12.3350 mL	61.6751 mL
10 mM	0.6168 mL	3.0838 mL	6.1675 mL	30.8375 mL
20 mM	0.3084 mL	1.5419 mL	3.0838 mL	15.4188 mL
50 mM	0.1234 mL	0.6168 mL	1.2335 mL	6.1675 mL
100 mM	0.0617 mL	0.3084 mL	0.6168 mL	3.0838 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc