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Procyclidine

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Catalog No. T60578Cas No. 77-37-2

Procyclidine (Tricyclamol; (±)-Procyclidine) is an anticholinergic agent that functions as a muscarinic receptor antagonist and an N-methyl-D-aspartate (NMDA) antagonist. It is used in studies of Parkinson's disease and related psychiatric disorders, including Soman-induced epilepsy [1][2].

Procyclidine
Other Forms of Procyclidine:
Procyclidine hydrochlorideT49791508-76-5
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Procyclidine

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Catalog No. T60578Cas No. 77-37-2
Procyclidine (Tricyclamol; (±)-Procyclidine) is an anticholinergic agent that functions as a muscarinic receptor antagonist and an N-methyl-D-aspartate (NMDA) antagonist. It is used in studies of Parkinson's disease and related psychiatric disorders, including Soman-induced epilepsy [1][2].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,5206-8 weeks6-8 weeks
50 mg$1,9806-8 weeks6-8 weeks
100 mg$2,5006-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Procyclidine (Tricyclamol; (±)-Procyclidine) is an anticholinergic agent that functions as a muscarinic receptor antagonist and an N-methyl-D-aspartate (NMDA) antagonist. It is used in studies of Parkinson's disease and related psychiatric disorders, including Soman-induced epilepsy [1][2].
In vivo
Procyclidine, when administered subcutaneously at dosages between 0.3-6.0 mg/kg in conjunction with physostigmine (PhS), exhibits increased dose-dependent protective effects against soman in rats and guinea pigs, significantly reducing or entirely preventing seizures. The study utilized male Sprague-Dawley rats and Dunkin-Hartley male guinea pigs, observing a substantial enhancement in protection. Specifically, protection levels in rats enhanced by 1.92, 2.24, 3.95, and 5.07 times, and in guinea pigs by 3.00, 3.25, 4.50, and 4.70 times at dosages of 0.3, 1.0, 3.0, and 6.0 mg/kg, respectively. This combination treatment safeguarded neurological brain integrity, effectively preventing severe damage in critical brain areas such as the hippocampus, cortex, amygdala, and thalamus induced by soman exposure.
Chemical Properties
Molecular Weight287.44
FormulaC19H29NO
Cas No.77-37-2
SmilesC(CCN1CCCC1)(O)(C2CCCCC2)C3=CC=CC=C3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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