Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PI3K-IN-47 (Compound 27) is a potent bivalent inhibitor targeting the phosphoinositide 3-kinases (PI3K) family, exhibiting inhibitory concentration (IC50) values of 0.44 nM for PI3Kα, and 7.18 nM, 13.92 nM, 22.83 nM for PI3Kβ, PI3Kγ, and PI3Kδ respectively. It is effective in inducing G1 phase cell cycle arrest, and exhibits anti-neoplastic properties by restraining colony formation and cell migration. Additionally, PI3K-IN-47 has demonstrated the ability to suppress tumor growth in HGC-27 xenograft mouse models [1].
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Description | PI3K-IN-47 (Compound 27) is a potent bivalent inhibitor targeting the phosphoinositide 3-kinases (PI3K) family, exhibiting inhibitory concentration (IC50) values of 0.44 nM for PI3Kα, and 7.18 nM, 13.92 nM, 22.83 nM for PI3Kβ, PI3Kγ, and PI3Kδ respectively. It is effective in inducing G1 phase cell cycle arrest, and exhibits anti-neoplastic properties by restraining colony formation and cell migration. Additionally, PI3K-IN-47 has demonstrated the ability to suppress tumor growth in HGC-27 xenograft mouse models [1]. |
Molecular Weight | 1027.07 |
Formula | C50H46F4N8O8S2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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PI3K-IN-47 PI3K/Akt/mTOR signaling PI3K inhibitor inhibit