Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CAF-382 (compound B1), an analog of SNS-032, functions as a CDKL5 and pan-CDK inhibitor, exhibiting modest inhibitory activity against GSK3α/β with an affinity greater than 1.8 μM. It effectively inhibits CDKL5 and impedes the phosphorylation of the CDKL5 E2 domain [1].
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Description | CAF-382 (compound B1), an analog of SNS-032, functions as a CDKL5 and pan-CDK inhibitor, exhibiting modest inhibitory activity against GSK3α/β with an affinity greater than 1.8 μM. It effectively inhibits CDKL5 and impedes the phosphorylation of the CDKL5 E2 domain [1]. |
In vitro | CAF-382 (Compound B1) at concentrations ranging from 5 nM to 5 μM resulted in a significant decrease in pSer222 EB2 levels at 5 nM, without altering the total EB2 levels [1]. |
Molecular Weight | 366.5 |
Formula | C16H22N4O2S2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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CAF-382 Cell Cycle/Checkpoint CDK inhibitor inhibit