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Lixisenatide

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Catalog No. TP1340 Copy Product Info
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Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist that primarily regulates glucose homeostasis by activating the GLP-1 signaling pathway. Beyond its glucose-lowering effects, lixisenatide suppresses inflammatory responses by downregulating pro-inflammatory cytokine expression and modulates signaling pathways such as Akt-MEK1/2. Additionally, it alleviates oxidative stress, mitochondrial dysfunction, and apoptosis, demonstrating potential value in research on metabolic diseases and inflammation-related conditions (e.g., diabetes and its complications).
Lixisenatide
Cas No. 320367-13-3
Pack SizePriceUSA StockGlobal StockQuantity
1 mg$98-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist that primarily regulates glucose homeostasis by activating the GLP-1 signaling pathway. Beyond its glucose-lowering effects, lixisenatide suppresses inflammatory responses by downregulating pro-inflammatory cytokine expression and modulates signaling pathways such as Akt-MEK1/2. Additionally, it alleviates oxidative stress, mitochondrial dysfunction, and apoptosis, demonstrating potential value in research on metabolic diseases and inflammation-related conditions (e.g., diabetes and its complications).
Chemical Properties
Molecular Weight4858.49
FormulaC215H347N61O65S
Cas No.320367-13-3
Relative Density.no data available
SequenceHis-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Ser-Lys-Lys-Lys-Lys-Lys-Lys-NH₂
Sequence ShortHGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPSKKKKKK
Storage & Solubility Information
StorageKeep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 80 mg/mL (16.47 mM), Sonication and heating are recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM0.2058 mL1.0291 mL2.0583 mL10.2913 mL
5 mM0.0412 mL0.2058 mL0.4117 mL2.0583 mL
10 mM0.0206 mL0.1029 mL0.2058 mL1.0291 mL
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Keywords

Related Tags: Lixisenatide chemical structure | Lixisenatide formula | Lixisenatide molecular weight