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Viloxazine

Name: Viloxazine
Brand: TargetMol
SKU: T60325
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60325Cas No. 46817-91-8

Alias Viloxazin, Emovit

Viloxazine (Viloxazin) (Viloxazin) is a dual-action compound that functions as a norepinephrine reuptake inhibitor and exhibits potent agonistic activity towards 5-HT 2C receptors while acting as an antagonist for 5-HT 2B receptors, with respective potency values of EC 50 = 32 μM and IC 50 = 27 μM. Its primary mechanism of action involves the modulation of serotonergic and noradrenergic pathways. Viloxazine is commonly employed in depression research [1] [2].

Viloxazine

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Purity: 99.65%

Catalog No. T60325Alias Viloxazin, EmovitCas No. 46817-91-8

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$34	-	In Stock
10 mg	$48	-	In Stock
25 mg	$98	-	In Stock
50 mg	$156	-	In Stock
100 mg	$247	-	In Stock
200 mg	$367	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.65%

Appearance:Liquid

Color:Transparent

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Viloxazine (Viloxazin) (Viloxazin) is a dual-action compound that functions as a norepinephrine reuptake inhibitor and exhibits potent agonistic activity towards 5-HT 2C receptors while acting as an antagonist for 5-HT 2B receptors, with respective potency values of EC 50 = 32 μM and IC 50 = 27 μM. Its primary mechanism of action involves the modulation of serotonergic and noradrenergic pathways. Viloxazine is commonly employed in depression research [1] [2].
Targets&IC50	5-HT2B:27 μM, 5-HT2C:32 μM(EC50)
In vivo	Viloxazine (1-16 mg/kg; spinal rat) stimulated the hind limb flexor reflex in the dose-dependent manner.[3]
Synonyms	Viloxazin, Emovit

Chemical Properties

Molecular Weight	237.29
Formula	C₁₃H₁₉NO₃
Cas No.	46817-91-8
Smiles	O(CC1CNCCO1)C2=C(OCC)C=CC=C2

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (252.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (10.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2143 mL	21.0713 mL	42.1425 mL	210.7126 mL
5 mM	0.8429 mL	4.2143 mL	8.4285 mL	42.1425 mL
10 mM	0.4214 mL	2.1071 mL	4.2143 mL	21.0713 mL
20 mM	0.2107 mL	1.0536 mL	2.1071 mL	10.5356 mL
50 mM	0.0843 mL	0.4214 mL	0.8429 mL	4.2143 mL
100 mM	0.0421 mL	0.2107 mL	0.4214 mL	2.1071 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc