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Demethylcantharidate disodium

Name: Demethylcantharidate disodium
Brand: TargetMol
SKU: T75637
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T75637 Copy Product Info

Purity: 99.97%

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Demethylcantharidate disodium is an endogenous metabolite that promotes apoptosis in hepatoma cells by inducing endoplasmic reticulum stress and shows favorable anticancer activity against various cancers.

Cas No. 129-67-9

Pack Size	Price	USA Stock	Global Stock
5 mg	$29	-	In Stock
10 mg	$40	-	In Stock
25 mg	$63	-	In Stock
50 mg	$92	-	In Stock
100 mg	$133	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.97%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Demethylcantharidate disodium is an endogenous metabolite that promotes apoptosis in hepatoma cells by inducing endoplasmic reticulum stress and shows favorable anticancer activity against various cancers.
In vitro	Methods: Hepatocellular carcinoma cells were treated with 0–100 μM demethylcantharidate disodium for 0, 12, 24, 48, or 72 h; separate treatments were also performed at 0, 9, 18, 36 μM for 24 h. Results: Demethylcantharidate disodium inhibited HCC cell proliferation and increased the levels of cleaved caspase‑3, cleaved caspase‑9, and the Bax/Bcl‑2 ratio in a dose‑dependent manner [1].
In vivo	Methods: An in vivo xenograft model of SMMC‑7721 hepatocellular carcinoma cells was established and treated with demethylcantharidate disodium. Results: Demethylcantharidate disodium significantly inhibited SMMC‑7721 cell‑mediated hepatocellular carcinoma tumorigenesis [1].

Chemical Properties

Molecular Weight	230.13
Formula	C₈H₈Na₂O₅
Cas No.	129-67-9
Smiles	O=C([O-])C1C2OC(CC2)C1C([O-])=O.[Na+].[Na+]

Storage & Solubility Information

Storage

Keep away from moistureKeep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 200 mg/mL (869.07 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	4.3454 mL	21.7269 mL	43.4537 mL	217.2685 mL
5 mM	0.8691 mL	4.3454 mL	8.6907 mL	43.4537 mL
10 mM	0.4345 mL	2.1727 mL	4.3454 mL	21.7269 mL
20 mM	0.2173 mL	1.0863 mL	2.1727 mL	10.8634 mL
50 mM	0.0869 mL	0.4345 mL	0.8691 mL	4.3454 mL
100 mM	0.0435 mL	0.2173 mL	0.4345 mL	2.1727 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: Demethylcantharidate disodium chemical structure | Demethylcantharidate disodium in vivo | Demethylcantharidate disodium in vitro | Demethylcantharidate disodium formula | Demethylcantharidate disodium molecular weight