Annexin V/ANXA5 Protein, Human, Recombinant

Name: Annexin V/ANXA5 Protein, Human, Recombinant
Brand: TargetMol
SKU: TMPY-02540
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: RPRGL3, PP4, HEL-S-7, ENX2, ANX5, annexin A5) Copy Product Info

Synonyms: RPRGL3, PP4, HEL-S-7, ENX2, ANX5, annexin A5

Catalog No. TMPY-02540 Copy Product Info

Annexin V/ANXA5 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 35.9 kDa and the accession number is P08758.

Pack Size	Price	USA Stock	Global Stock
5 µg	$48	-	In Stock
10 µg	$77	-	In Stock
20 µg	$123	-	In Stock
50 µg	$238	7-10 days	7-10 days
100 µg	$398	-	In Stock
200 µg	$645	7-10 days	7-10 days
500 µg	$1,220	7-10 days	7-10 days
1 mg	$2,000	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:> 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC

Appearance:Lyophilized powder

Color:White

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COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Annexin V/ANXA5 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 35.9 kDa and the accession number is P08758.
Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	P08758
Construction	Ala2-Asp320
Protein Purity	> 90 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in 50mM Tris, 240mM NaCl (pH 8.5). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	RPRGL3, PP4, HEL-S-7, ENX2, ANX5, annexin A5
Research Background	The placental anticoagulant protein Annexin A5 (ANXA5) is a multifunctional protein that is highly expressed on the apical surfaces of syncytiotrophoblasts, and plays an important role in haemostatic regulations, maintaining blood fluidity of the placenta. Annexin A5 (ANXA5) is a protein abundantly expressed in normal placenta where it contributes to the healthy outcome of a pregnancy. Lower ANXA5 levels have been observed in M2/ANXA5 haplotype carrying chorion. The association found between the maternal carriage of the M2/ANXA5 haplotype and an elevated risk of IUGR and/or PE supports the hypothesis that carrier status of this haplotype and the consequently reduced placental ANXA5 expression might be responsible, at least partially, for the onset of these gestational vascular complications. ANXA5 could be used as a biomarker for the early detection of PE and for the prediction of its severity. ANXA5 as an embryonic anticoagulant that appears deficient in contiguous specter of thrombophilia-related pregnancy complications culminating more frequently in miscarriage in a maternal M2 carrier background. As a potential indicator for malignancy and lymphatic metastasis, ANXA5 overexpression increases in vitro migration and invasion of Hca-P cell, promotes in vivo malignancy, LNM rate and level of Hca-P-transplanted mice. Hereditary thrombophilias can impair vascular placental functions and predispose to the birth of small-for-gestational age (SGA) babies. The placental anticoagulant protein annexin A5 (ANXA5) may contribute to this process. A functional haplotype (M2) within the ANXA5 gene is associated with fetal loss and venous thrombosis.

Chemical Properties

Molecular Weight

35.9 kDa (reducing condition)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.