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PF-06647263
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Catalog No. T77462Cas No. 1822383-65-2
Alias PF06647263, anti-EFNA4-ADC
PF-06647263 (anti-EFNA4-ADC) is an ADC compound targeting EFNA4, with anti-tumor activity, composed of an anti-EFNA4 antibody conjugated with calicheamicin, inducing significant tumor regression in TNBC xenografts.
PF-06647263
PF-06647263
🥰Excellent
Catalog No. T77462Alias PF06647263, anti-EFNA4-ADCCas No. 1822383-65-2
PF-06647263 (anti-EFNA4-ADC) is an ADC compound targeting EFNA4, with anti-tumor activity, composed of an anti-EFNA4 antibody conjugated with calicheamicin, inducing significant tumor regression in TNBC xenografts.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $447 | - | In Stock | |
| 5 mg | $1,400 | - | In Stock | |
| 10 mg | $2,240 | - | In Stock | |
| 25 mg | $4,210 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Concentration:4.56 mg/mL
Purity:99.31% (SEC-HPLC)
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Product Introduction
Bioactivity
Chemical Properties
| Description | PF-06647263 (anti-EFNA4-ADC) is an ADC compound targeting EFNA4, with anti-tumor activity, composed of an anti-EFNA4 antibody conjugated with calicheamicin, inducing significant tumor regression in TNBC xenografts. |
| Targets&IC50 | 293T-EFNA4 cells:1 ng/mL (EC50) |
| In vitro | PF-06647263 induces antigenic and concentration-dependent cytotoxicity, and exposure to PF-06647263 for 96 hours causes 293T-EFNA4 cell death (EC50 ≈ 1 ng/mL). [1] |
| In vivo | In mice with a breast PDX tumor model, 0.27 mg/kg PF-06647263 resulted in significant tumor regression. [1] |
| Synonyms | PF06647263, anti-EFNA4-ADC |
| Molecular Weight | 145.5 kDa |
| Cas No. | 1822383-65-2 |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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