Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CYT296 is a chromatin de-condensation agent that enhances the efficiency of induced pluripotent stem cell (iPSC) generation mediated by defined factors (OSKM) and promotes an open chromatin state in Mouse Embryonic Fibroblast (MEFs), aiding in somatic cell reprogramming. This compound has potential applications in cell replacement therapies and drug screening research [1].
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Description | CYT296 is a chromatin de-condensation agent that enhances the efficiency of induced pluripotent stem cell (iPSC) generation mediated by defined factors (OSKM) and promotes an open chromatin state in Mouse Embryonic Fibroblast (MEFs), aiding in somatic cell reprogramming. This compound has potential applications in cell replacement therapies and drug screening research [1]. |
In vitro | CYT296 (250nM, 72 hours) alters the chromatin architecture in MEFs to facilitate Yamanaka factor accessibility and enhance the reprogramming process [1]. Additionally, CYT296 (250nM, 72 hours) as a small-molecule inhibitor disrupts heterochromatin assembly in MEFs, significantly improving the generation of iPSCs [1]. |
In vivo | CYT296, administered subcutaneously in a single dose (皮下注射, 一次), effectively induced pluripotency [1] in iPSCs derived from NOD-SCID mice, with tests conducted on 10-15 4F- and 2F-iPSC clones. |
Molecular Weight | 296.38 |
Formula | C18H16O2S |
CAS No. | 1799392-31-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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CYT296 1799392-31-6 Others inhibitor inhibit