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Neuromedin U-25 (human)

Name: Neuromedin U-25 (human)
Brand: TargetMol
SKU: TP2609
Rating: 4.5 (1 reviews)

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Catalog No. TP2609Cas No. 312306-89-1

Neuromedin U-25 human, the active form of neuromedin U in humans, inhibits glucose-stimulated insulin secretion, leading to early-onset obesity, and serves as a vasoconstrictor in human vascular beds [1][2].

Neuromedin U-25 (human)

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Catalog No. TP2609Cas No. 312306-89-1

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Product Introduction

Bioactivity

Description	Neuromedin U-25 human, the active form of neuromedin U in humans, inhibits glucose-stimulated insulin secretion, leading to early-onset obesity, and serves as a vasoconstrictor in human vascular beds [1][2].
In vitro	Neuromedin U-25 human (4 pM-2 nM) binds to receptors in the human left ventricle and coronary artery, with K D values of 0.26 and 0.11 nM, respectively [1]. Additionally, Neuromedin U-25 human (0.1 nM-0.1 μM) induces endothelium-independent contraction in coronary, mammary, and saphenous vessels, with contraction potencies (pD 2) of 8.6, 8.0, and 8.2, respectively [1].

Chemical Properties

Molecular Weight	3080.37
Formula	C₁₄₁H₂₀₃N₄₁O₃₈
Cas No.	312306-89-1
Sequence	Phe-Arg-Val-Asp-Glu-Glu-Phe-Gln-Ser-Pro-Phe-Ala-Ser-Gln-Ser-Arg-Gly-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2
Sequence Short	FRVDEEFQSPFASQSRGYFLFRPRN-NH2

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Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

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