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MC-VA-PAB-Exatecan

Name: MC-VA-PAB-Exatecan
Brand: TargetMol
SKU: T77854
Price: 348 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77854Cas No. 2680543-57-9

MC-VA-PAB-Exatecan is a drug-linker conjugate used for synthesising ADCs, containing an ADC linker (MC-VA-PAB) and the topoisomerase I inhibitor Exatecan, which exhibits antitumour activity.

MC-VA-PAB-Exatecan

🥰Excellent

Catalog No. T77854Cas No. 2680543-57-9

MC-VA-PAB-Exatecan is a drug-linker conjugate used for synthesising ADCs, containing an ADC linker (MC-VA-PAB) and the topoisomerase I inhibitor Exatecan, which exhibits antitumour activity.

Pack Size	Price	Availability	Quantity
2 mg	$348	In Stock

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Product Introduction

Bioactivity

Description

MC-VA-PAB-Exatecan is a drug-linker conjugate used for synthesising ADCs, containing an ADC linker (MC-VA-PAB) and the topoisomerase I inhibitor Exatecan, which exhibits antitumour activity.

Chemical Properties

Molecular Weight	948.02
Formula	C₅₀H₅₄FN₇O₁₁
Cas No.	2680543-57-9
Smiles	N(C(OCC1=CC=C(NC([C@@H](NC([C@@H](NC(CCCCCN2C(=O)C=CC2=O)=O)[C@@H](C)C)=O)C)=O)C=C1)=O)[C@@H]3C4=C5C(C=6N(C5)C(=O)C7=C(C6)[C@](CC)(O)C(=O)OC7)=NC=8C4=C(CC3)C(C)=C(F)C8

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMF: ≥ 80 mg/mL, Sonication is recommended.

DMSO: 80.00 mg/mL (84.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0548 mL	5.2742 mL	10.5483 mL	52.7415 mL
5 mM	0.2110 mL	1.0548 mL	2.1097 mL	10.5483 mL
10 mM	0.1055 mL	0.5274 mL	1.0548 mL	5.2742 mL
20 mM	0.0527 mL	0.2637 mL	0.5274 mL	2.6371 mL
50 mM	0.0211 mL	0.1055 mL	0.2110 mL	1.0548 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc