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Leucettinib-92

Catalog No. T79562 CAS 2732859-57-1

Leucettinib-92 (compound 92) is a kinase inhibitor selective for DYRK/CLK families, displaying IC50 values of 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μM (CLK3), 124 nM (DYRK1A), 204 nM (DYRK1B), 0.16 μM (DYRK2), 1.0 μM (DYRK3), 0.52 μM (DYRK4), and 2.78 μM (GSK3) [1].

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Leucettinib-92, CAS 2732859-57-1

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Description	Leucettinib-92 (compound 92) is a kinase inhibitor selective for DYRK/CLK families, displaying IC50 values of 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μM (CLK3), 124 nM (DYRK1A), 204 nM (DYRK1B), 0.16 μM (DYRK2), 1.0 μM (DYRK3), 0.52 μM (DYRK4), and 2.78 μM (GSK3) [1].
In vitro	Leucettinib-92 (0.1-10 μM; 3 min) binds to DYRK1A in SH-SY5Y cells, stabilizing it to withstand melting temperatures above 52°C. Additionally, at a concentration of 1 μM, Leucettinib-92 inhibits the phosphorylation of two DYRK1A substrates, Thr212-Tau and Thr286-cyclin D1 [1].

Molecular Weight	378.49
Formula	C21H22N4OS
CAS No.	2732859-57-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

Leucettinib-92 2732859-57-1 Cell Cycle/Checkpoint CDK inhibitor inhibit

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