ACVR2A Protein, Human, Recombinant (hFc)

Catalog No. TMPY-00659

ACVR2A Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is P27037-1(Human)/G7PKJ4(Cynomolgus).

ACVR2A Protein, Human, Recombinant (hFc)

Catalog No. TMPY-00659

ACVR2A Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is P27037-1(Human)/G7PKJ4(Cynomolgus).

Pack Size	Price	USA Warehouse	Global Warehouse
5 μg	$59	7-10 days	7-10 days
10 μg	$95	7-10 days	7-10 days
20 μg	$155	7-10 days	7-10 days
50 μg	$296	7-10 days	7-10 days
100 μg	$497	7-10 days	7-10 days
200 μg	$987	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse [1-2 days] Global Warehouse [5-7 days]

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Product Information

Biological Activity	Immobilized Human Activin A, No Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Human/Cynomolgus Activin RIIA, hFc Tag with the EC50 of 1.6ng/ml determined by ELISA (QC Test). Immobilized Human/Mouse/Rat GDF-8, No Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Human/Cynomolgus Activin RIIA, hFc Tag with the EC50 of 56.9ng/ml determined by ELISA. Human Activin RIIA, hFc Tag captured on CM5 Chip via Protein A can bind Human/Mouse/Rat GDF-8, No Tag with an affinity constant of 0.13 nM as determined in SPR assay (Biacore T200).
Description	ACVR2A Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is P27037-1(Human)/G7PKJ4(Cynomolgus).
Species	Human,Cynomolgus
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	P27037-1(Human)/G7PKJ4(Cynomolgus)
Synonyms	ACVR2,ACTRII,activin A receptor, type IIA
Construction	Ala20-Pro135
Protein Purity	> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
Molecular Weight	39.35 kDa (Predicted); 55-65 kDa (Reducing conditions due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Activin A receptor type 2A (ACVR2A) is a membrane receptor in the transforming growth factor- beta (TGF-β signaling pathway, which is involved in the regulation of cell proliferation, migration, and apoptosis. Loss of ACVR2A has an important role in cancer progression and distant metastasis and may serve as a prognostic marker in patients with colon cancer.