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CFTR corrector 8

🥰Excellent
Catalog No. T63806Cas No. 1918142-35-4

CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). This compound is specifically designed for utilization in research related to cystic fibrosis, a genetic disorder primarily affecting the lungs and digestive system [1].

CFTR corrector 8

CFTR corrector 8

🥰Excellent
Purity: 99.58%
Catalog No. T63806Cas No. 1918142-35-4
CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). This compound is specifically designed for utilization in research related to cystic fibrosis, a genetic disorder primarily affecting the lungs and digestive system [1].
Pack SizePriceAvailabilityQuantity
1 mg$31In Stock
5 mg$75In Stock
10 mg$117In Stock
25 mg$236In Stock
50 mg$371In Stock
100 mg$609In Stock
200 mg$819In Stock
1 mL x 10 mM (in DMSO)$97In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.58%
ee:99.26%
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COA FNMR HPLC CSFC HNMR ORP

Product Introduction

Bioactivity
Description
CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). This compound is specifically designed for utilization in research related to cystic fibrosis, a genetic disorder primarily affecting the lungs and digestive system [1].
In vitro
CFTR corrector 8 demonstrates EC50 values of 1 μM in the CSE-HRP assay and 3 μM in the HBE-TECC assay.[1]
CFTR corrector 8 displays a hepatocyte clearance rate of 1250 L/hr/kg in humans and 775 L/hr/kg in rats.[1]
Chemical Properties
Molecular Weight539.52
FormulaC29H27F2NO7
Cas No.1918142-35-4
SmilesCOc1ccc2[C@H](C[C@H](Oc2c1)c1ccc(OC)c(OC)c1)NC(=O)C1(CC1)c1ccc2OC(F)(F)Oc2c1
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 10 mg/mL (18.53 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8535 mL9.2675 mL18.5350 mL92.6750 mL
5 mM0.3707 mL1.8535 mL3.7070 mL18.5350 mL
10 mM0.1853 mL0.9267 mL1.8535 mL9.2675 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

CFTR
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