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T-5342126

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Catalog No. T35864Cas No. 956507-49-6

T-5342126 is a toll-like receptor 4 (TLR4) antagonist that reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 27.8 μM) and decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) also reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.

T-5342126

T-5342126

😃Good
Catalog No. T35864Cas No. 956507-49-6
T-5342126 is a toll-like receptor 4 (TLR4) antagonist that reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 27.8 μM) and decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) also reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.
Pack SizePriceAvailabilityQuantity
1 mg$19835 days
5 mg$84535 days
10 mg$1,43035 days
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Product Introduction

Bioactivity
Description
T-5342126 is a toll-like receptor 4 (TLR4) antagonist that reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 27.8 μM) and decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) also reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.
Chemical Properties
Molecular Weight457.99
FormulaC25H32ClN3O3
Cas No.956507-49-6
Relative Density.1.16 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Methyl Acetate: 10 mg/mL (21.83 mM), Sonication is recommended.
Solution Preparation Table
Methyl Acetate
1mg5mg10mg50mg
1 mM2.1835 mL10.9173 mL21.8345 mL109.1727 mL
5 mM0.4367 mL2.1835 mL4.3669 mL21.8345 mL
10 mM0.2183 mL1.0917 mL2.1835 mL10.9173 mL
20 mM0.1092 mL0.5459 mL1.0917 mL5.4586 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

T 5342126T-5342126T5342126
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