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Evodiamine

Name: Evodiamine
Brand: TargetMol
SKU: T2868
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2868Cas No. 518-17-2

Alias Isoevodiamine, d-Evodiamine, (+)-Evodiamine

Evodiamine (d-Evodiamine) is an alkaloid isolated from the fruit of daylily and has a variety of biological activities including anti-inflammatory, anti-obesity and anti-tumor.

Evodiamine

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Purity: 99.94%

Catalog No. T2868Alias Isoevodiamine, d-Evodiamine, (+)-EvodiamineCas No. 518-17-2

Evodiamine (d-Evodiamine) is an alkaloid isolated from the fruit of daylily and has a variety of biological activities including anti-inflammatory, anti-obesity and anti-tumor.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$42	In Stock	In Stock
100 mg	$54	In Stock	In Stock
500 mg	$129	In Stock	In Stock
1 g	$192	-	In Stock
5 g	$477	-	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.94%

Color:White

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Product Introduction

Bioactivity

Description	Evodiamine (d-Evodiamine) is an alkaloid isolated from the fruit of daylily and has a variety of biological activities including anti-inflammatory, anti-obesity and anti-tumor.
In vitro	In mice, the LD50 of intravenously injected Evodiamine is 77 mg/kg.
In vivo	In U937 cells with overexpressed Bcl-2 and Akt, evodiamine induces apoptosis through a caspase-independent cell death pathway.
Cell Research	Evodiamine is dissolved in DMSO and diluted with appropriate medium before use. The evodiamine-inspired new scaffolds are assayed for growth inhibitory activities toward human cancer cell-lines A549 (lung cancer), MDA-MB-435 (breast cancer) and HCT116 (colon cancer) using the MTT assay. Evodiamine and camptithecin are used as reference drugs[1].
Synonyms	Isoevodiamine, d-Evodiamine, (+)-Evodiamine

Chemical Properties

Molecular Weight	303.36
Formula	C₁₉H₁₇N₃O
Cas No.	518-17-2
Smiles	CN1[C@@]2(C3=C(C=4C(N3)=CC=CC4)CCN2C(=O)C=5C1=CC=CC5)[H]
Relative Density.	1.1684 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20.2 mg/mL (66.59 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2964 mL	16.4821 mL	32.9641 mL	164.8207 mL
5 mM	0.6593 mL	3.2964 mL	6.5928 mL	32.9641 mL
10 mM	0.3296 mL	1.6482 mL	3.2964 mL	16.4821 mL
20 mM	0.1648 mL	0.8241 mL	1.6482 mL	8.2410 mL
50 mM	0.0659 mL	0.3296 mL	0.6593 mL	3.2964 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc