Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PROTAC α-synuclein degrader 5 is a highly selective (PROTAC) compound that targets and degrades α-synuclein aggregates, exhibiting an DC50 value of 7.51 μM and achieving a maximum degradation rate (Dmax) of 89%. The compound incorporates the probe molecule sery308 and E3 ligase ligands, making it suitable for neurological disease research [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 35 days | $ 987.00 |
Description | PROTAC α-synuclein degrader 5 is a highly selective (PROTAC) compound that targets and degrades α-synuclein aggregates, exhibiting an DC50 value of 7.51 μM and achieving a maximum degradation rate (Dmax) of 89%. The compound incorporates the probe molecule sery308 and E3 ligase ligands, making it suitable for neurological disease research [1]. |
In vitro | PROTAC α-synuclein degrader 5 (Compound 2b) administered at concentrations ranging from 0 to 40 μM over a 48-hour period reduced levels of α-synuclein aggregates in a cell model inoculated with PFF [1]. Furthermore, at a concentration range of 0 to 10 μM for 48 hours, the degrader decreased α-synuclein aggregates in a dose-dependent manner, evidenced by reductions in both the number and density of α-synuclein positive spots, as well as a gradual decline in fluorescence intensity [1]. |
Molecular Weight | 767.78 |
Formula | C39H41N7O10 |
CAS No. | 2781922-42-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PROTAC α-synuclein degrader 5 2781922-42-5 PROTAC PROTACs inhibitor inhibit