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PROTAC α-synuclein degrader 5

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Catalog No. T79250Cas No. 2781922-42-5

PROTAC α-synuclein degrader 5 is a highly selective (PROTAC) compound targeting and degrading α-synuclein aggregates, with a DC50 value of 7.51 μM and a maximum degradation rate (Dmax) of 89%. It incorporates the probe molecule sery308 and E3 ligase ligands, suitable for neurological disease research [1].

PROTAC α-synuclein degrader 5

PROTAC α-synuclein degrader 5

😃Good
Catalog No. T79250Cas No. 2781922-42-5
PROTAC α-synuclein degrader 5 is a highly selective (PROTAC) compound targeting and degrading α-synuclein aggregates, with a DC50 value of 7.51 μM and a maximum degradation rate (Dmax) of 89%. It incorporates the probe molecule sery308 and E3 ligase ligands, suitable for neurological disease research [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$1,43035 days35 days
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Product Introduction

Bioactivity
Description
PROTAC α-synuclein degrader 5 is a highly selective (PROTAC) compound targeting and degrading α-synuclein aggregates, with a DC50 value of 7.51 μM and a maximum degradation rate (Dmax) of 89%. It incorporates the probe molecule sery308 and E3 ligase ligands, suitable for neurological disease research [1].
In vitro
PROTAC α-synuclein degrader 5 (Compound 2b) administered at concentrations ranging from 0 to 40 μM over a 48-hour period reduced α-synuclein aggregates in a cell model inoculated with PFF [1]. At concentrations from 0 to 10 μM for 48 hours, it decreased α-synuclein aggregates dose-dependently, reducing the number and density of α-synuclein positive spots, along with a gradual decline in fluorescence intensity [1].
Chemical Properties
Molecular Weight767.78
FormulaC39H41N7O10
Cas No.2781922-42-5
SmilesO=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCOCCNC(CNC4=CC(=CC=C4)C=5C=C(NN5)C=6C=C7C(=CC6)OCO7)=O
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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