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TUG-469 (Synonyms: TUG469, TUG 469)

Name: TUG-469
Brand: TargetMol
SKU: T34967
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T34967 Copy Product Info

Purity: 99.73%

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TUG-469 is an agonist of free fatty acid 1(FFA) receptor.

TUG-469

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Catalog No. T34967

Synonyms TUG469, TUG 469

TUG-469 is an agonist of free fatty acid 1(FFA) receptor.

Cas No. 1236109-67-3

Pack Size	Price	USA Stock	Global Stock	Quantity
25 mg	$47	-	In Stock
50 mg	Preferential	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.73%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

TUG-469 AI Summary

TUG-469 is a potent agonist at the human FFA1 (GPR40) receptor, demonstrating high efficacy and selectivity over PPARgamma, with an EC50 value of 18.62 nM in 1321N1 cells and 11.22 nM in competitive binding assays. The compound also activates GPR120, albeit with moderate efficacy (53.0%). It effectively induces glucose-stimulated insulin secretion in rat INS-1E cells and mouse islets, showing glucose-dependent insulinotropic activity. In calcium mobilization assays, its activity varies depending on the presence of bovine serum albumin, with potent efficacy illustrated. TUG-469 displays excellent oral bioavailability, rapid onset of action, and stability in human liver microsomes, with a LogD of 2.49. These characteristics indicate its potential as a promising pharmacological agent, specifically for targeting FFA1 in therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	TUG-469 is an agonist of free fatty acid 1(FFA) receptor.
Synonyms	TUG469, TUG 469

Chemical Properties

Molecular Weight	345.43
Formula	C₂₃H₂₃NO₂
Cas No.	1236109-67-3
Smiles	Cc1ccccc1-c1cccc(CNc2ccc(CCC(O)=O)cc2)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (260.54 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8949 mL	14.4747 mL	28.9494 mL	144.7471 mL
5 mM	0.5790 mL	2.8949 mL	5.7899 mL	28.9494 mL
10 mM	0.2895 mL	1.4475 mL	2.8949 mL	14.4747 mL
20 mM	0.1447 mL	0.7237 mL	1.4475 mL	7.2374 mL
50 mM	0.0579 mL	0.2895 mL	0.5790 mL	2.8949 mL
100 mM	0.0289 mL	0.1447 mL	0.2895 mL	1.4475 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc