MSI-1436

Name: MSI-1436
Brand: TargetMol
SKU: T12116
Rating: 4.5 (1 reviews)

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Catalog No. T12116Cas No. 186139-09-3

Alias Trodusquemine, Aminosterol-1436

MSI-1436 is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTB1B) with an IC50 of approximately 1 μM.

MSI-1436

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Catalog No. T12116Alias Trodusquemine, Aminosterol-1436Cas No. 186139-09-3

MSI-1436 is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTB1B) with an IC50 of approximately 1 μM.

Pack Size	Price	Availability
25 mg	$2,670	8-10 weeks
50 mg	$4,220	8-10 weeks
100 mg	$6,750	8-10 weeks

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Product Introduction

Bioactivity

Description	MSI-1436 is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTB1B) with an IC50 of approximately 1 μM.
Targets&IC50	TCPTP:224 μM , PTB1B:1 μM
In vitro	Trodusquemine significantly enhanced insulin-stimulated tyrosine phosphorylation of insulin receptor (IR) beta and STAT3, direct targets of PTP1B, in HepG2 cells in vitro and/or hypothalamic tissue[1].
In vivo	Trodusquemine (MSI-1436) causes rapid and reversible weight loss in genetic models of obesity.?Trodusquemine suppressed appetite, reduced body weight (BW) in a fat-specific manner, and improved plasma insulin and leptin levels in mice[1].
Synonyms	Trodusquemine, Aminosterol-1436

Chemical Properties

Molecular Weight	685.06
Formula	C₃₇H₇₂N₄O₅S
Cas No.	186139-09-3
Relative Density.	1.12 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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