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Neurokinin A TFA

Name: Neurokinin A TFA
Brand: TargetMol
SKU: T75729
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T75729Cas No. 2828433-19-6

Alias Substance K TFA, NKA TFA, Neuromedin L TFA, Neurokinin α TFA

Neurokinin A TFA (NKA TFA) is a neuropeptide within the neurokinin family, serving as the endogenous ligand and agonist for the NK-2 (Neurokinin 2) receptor. It regulates the nervous system, inflammation, and pain, and is applicable for research into asthma, inflammatory bowel disease, rheumatoid arthritis pain, and psychiatric disorders.

Neurokinin A TFA

🥰Excellent

Purity: 98.704%

Catalog No. T75729Alias Substance K TFA, NKA TFA, Neuromedin L TFA, Neurokinin α TFACas No. 2828433-19-6

Pack Size	Price	Availability
1 mg	$52	In Stock
5 mg	$123	In Stock
10 mg	$213	In Stock
25 mg	$359	In Stock
50 mg	$533	In Stock
100 mg	$759	In Stock
200 mg	$987	In Stock

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Purity:98.704%

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COA HPLC MS

Product Introduction

Bioactivity

Description	Neurokinin A TFA (NKA TFA) is a neuropeptide within the neurokinin family, serving as the endogenous ligand and agonist for the NK-2 (Neurokinin 2) receptor. It regulates the nervous system, inflammation, and pain, and is applicable for research into asthma, inflammatory bowel disease, rheumatoid arthritis pain, and psychiatric disorders.
In vitro	Neurokinin A TFA is a peptide neurotransmitter belonging to the tachykinin family. All tachykinins share a conserved COOH-terminal structure of Phe-X-Gly-Leu-Met-NH₂, and the most representative members of this family are Substance P and Neurokinin A. Neurokinin A TFA may act as a crucial mediator in human airway and gastrointestinal tissues. It exerts its effects through NK-2 receptors localized on smooth muscle cells and is pharmacologically coupled to GTP-binding proteins. Neurokinin A TFA is associated with both the central and peripheral nervous systems and exhibits a broad tissue distribution pattern. [1]
Synonyms	Substance K TFA, NKA TFA, Neuromedin L TFA, Neurokinin α TFA

Chemical Properties

Molecular Weight	1247.34
Formula	C₅₂H₈₁F₃N₁₄O₁₆S
Cas No.	2828433-19-6
Smiles	C(C(O)=O)(F)(F)F.[C@H](CC1=CC=CC=C1)(C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CCSC)C(N)=O)=O)CC(C)C)=O)=O)C(C)C)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CN=CN2)N)=O)CCCCN)=O)[C@@H](C)O)=O)CC(O)=O)=O)CO)=O
Color	White
Appearance	Solid
Sequence	His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2
Sequence Short	HKTDSFVGLM-NH2

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (64.14 mM), Sonication is recommended.

H2O: 40 mg/mL (32.07 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8017 mL	4.0085 mL	8.0171 mL	40.0853 mL
5 mM	0.1603 mL	0.8017 mL	1.6034 mL	8.0171 mL
10 mM	0.0802 mL	0.4009 mL	0.8017 mL	4.0085 mL
20 mM	0.0401 mL	0.2004 mL	0.4009 mL	2.0043 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0160 mL	0.0802 mL	0.1603 mL	0.8017 mL

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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