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Neurokinin A TFA
😃Good
Catalog No. T75729Cas No. 2828433-19-6
Alias Substance K TFA, NKA TFA, Neuromedin L TFA, Neurokinin α TFA
Neurokinin A TFA (NKA TFA) is a neuropeptide within the neurokinin family, serving as the endogenous ligand and agonist for the NK-2 (Neurokinin 2) receptor. It regulates the nervous system, inflammation, and pain, and is applicable for research into asthma, inflammatory bowel disease, rheumatoid arthritis pain, and psychiatric disorders.
Neurokinin A TFA
😃Good
Purity: 98.70%
Catalog No. T75729Alias Substance K TFA, NKA TFA, Neuromedin L TFA, Neurokinin α TFACas No. 2828433-19-6
Neurokinin A TFA (NKA TFA) is a neuropeptide within the neurokinin family, serving as the endogenous ligand and agonist for the NK-2 (Neurokinin 2) receptor. It regulates the nervous system, inflammation, and pain, and is applicable for research into asthma, inflammatory bowel disease, rheumatoid arthritis pain, and psychiatric disorders.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $52 | - | In Stock | |
| 5 mg | $123 | - | In Stock | |
| 10 mg | $213 | - | In Stock | |
| 25 mg | $359 | - | In Stock | |
| 50 mg | $533 | - | In Stock | |
| 100 mg | $759 | - | In Stock | |
| 200 mg | $987 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.70%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Neurokinin A TFA (NKA TFA) is a neuropeptide within the neurokinin family, serving as the endogenous ligand and agonist for the NK-2 (Neurokinin 2) receptor. It regulates the nervous system, inflammation, and pain, and is applicable for research into asthma, inflammatory bowel disease, rheumatoid arthritis pain, and psychiatric disorders. |
| In vitro | Neurokinin A TFA is a peptide neurotransmitter belonging to the tachykinin family. All tachykinins share a conserved COOH-terminal structure of Phe-X-Gly-Leu-Met-NH₂, and the most representative members of this family are Substance P and Neurokinin A. Neurokinin A TFA may act as a crucial mediator in human airway and gastrointestinal tissues. It exerts its effects through NK-2 receptors localized on smooth muscle cells and is pharmacologically coupled to GTP-binding proteins. Neurokinin A TFA is associated with both the central and peripheral nervous systems and exhibits a broad tissue distribution pattern. [1] |
| Synonyms | Substance K TFA, NKA TFA, Neuromedin L TFA, Neurokinin α TFA |
| Molecular Weight | 1247.34 |
| Formula | C52H81F3N14O16S |
| Cas No. | 2828433-19-6 |
| Smiles | C(C(O)=O)(F)(F)F.[C@H](CC1=CC=CC=C1)(C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CCSC)C(N)=O)=O)CC(C)C)=O)=O)C(C)C)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CN=CN2)N)=O)CCCCN)=O)[C@@H](C)O)=O)CC(O)=O)=O)CO)=O |
| Sequence | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 |
| Sequence Short | HKTDSFVGLM |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (64.14 mM), Sonication is recommended. H2O: 40 mg/mL (32.07 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (2.65 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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