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Neurokinin A TFA

Name: Neurokinin A TFA
Brand: TargetMol
SKU: T75729
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T75729Cas No. 2828433-19-6

Alias Substance K TFA, NKA TFA, Neuromedin L TFA, Neurokinin α TFA

Neurokinin A TFA (NKA TFA) is a neuropeptide within the neurokinin family, serving as the endogenous ligand and agonist for the NK-2 (Neurokinin 2) receptor. It regulates the nervous system, inflammation, and pain, and is applicable for research into asthma, inflammatory bowel disease, rheumatoid arthritis pain, and psychiatric disorders.

Neurokinin A TFA

🥰Excellent

Purity: 98.704%

Catalog No. T75729Alias Substance K TFA, NKA TFA, Neuromedin L TFA, Neurokinin α TFACas No. 2828433-19-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	-	In Stock
5 mg	$123	-	In Stock
10 mg	$213	-	In Stock
25 mg	$359	-	In Stock
50 mg	$533	-	In Stock
100 mg	$759	-	In Stock
200 mg	$987	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.704%

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COA HPLC MS

Product Introduction

Bioactivity

Description	Neurokinin A TFA (NKA TFA) is a neuropeptide within the neurokinin family, serving as the endogenous ligand and agonist for the NK-2 (Neurokinin 2) receptor. It regulates the nervous system, inflammation, and pain, and is applicable for research into asthma, inflammatory bowel disease, rheumatoid arthritis pain, and psychiatric disorders.
In vitro	Neurokinin A TFA is a peptide neurotransmitter belonging to the tachykinin family. All tachykinins share a conserved COOH-terminal structure of Phe-X-Gly-Leu-Met-NH₂, and the most representative members of this family are Substance P and Neurokinin A. Neurokinin A TFA may act as a crucial mediator in human airway and gastrointestinal tissues. It exerts its effects through NK-2 receptors localized on smooth muscle cells and is pharmacologically coupled to GTP-binding proteins. Neurokinin A TFA is associated with both the central and peripheral nervous systems and exhibits a broad tissue distribution pattern. [1]
Synonyms	Substance K TFA, NKA TFA, Neuromedin L TFA, Neurokinin α TFA

Chemical Properties

Molecular Weight	1247.34
Formula	C₅₂H₈₁F₃N₁₄O₁₆S
Cas No.	2828433-19-6
Smiles	C(C(O)=O)(F)(F)F.[C@H](CC1=CC=CC=C1)(C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CCSC)C(N)=O)=O)CC(C)C)=O)=O)C(C)C)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CN=CN2)N)=O)CCCCN)=O)[C@@H](C)O)=O)CC(O)=O)=O)CO)=O
Color	White
Appearance	Solid
Sequence	His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2
Sequence Short	HKTDSFVGLM-NH2

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (64.14 mM), Sonication is recommended.

H2O: 40 mg/mL (32.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (2.65 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8017 mL	4.0085 mL	8.0171 mL	40.0853 mL
5 mM	0.1603 mL	0.8017 mL	1.6034 mL	8.0171 mL
10 mM	0.0802 mL	0.4009 mL	0.8017 mL	4.0085 mL
20 mM	0.0401 mL	0.2004 mL	0.4009 mL	2.0043 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0160 mL	0.0802 mL	0.1603 mL	0.8017 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Neurokinin A TFA

Neurokinin A TFA

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