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Paluratide
🥰Excellent
Catalog No. T79673Cas No. 2676177-63-0
Alias LUNA18, LUNA 18
Paluratide (LUNA18) is a reversible cyclic peptide KRAS inhibitor with the advantages of oral availability and cell permeability for the treatment of kras-mutant cancers, which inhibits cancer cell proliferation by phosphorylating ERK and AKT, and also inhibits the interaction of RAS with guanine nucleotide exchange factors (GEFs).
Paluratide
🥰Excellent
Purity: 98.70%
Catalog No. T79673Alias LUNA18, LUNA 18Cas No. 2676177-63-0
Paluratide (LUNA18) is a reversible cyclic peptide KRAS inhibitor with the advantages of oral availability and cell permeability for the treatment of kras-mutant cancers, which inhibits cancer cell proliferation by phosphorylating ERK and AKT, and also inhibits the interaction of RAS with guanine nucleotide exchange factors (GEFs).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $1,180 | In Stock | |
| 5 mg | $3,280 | In Stock | |
| 10 mg | $4,450 | In Stock | |
| 25 mg | $6,620 | In Stock | |
| 50 mg | $8,930 | In Stock |
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Purity:98.70%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Paluratide (LUNA18) is a reversible cyclic peptide KRAS inhibitor with the advantages of oral availability and cell permeability for the treatment of kras-mutant cancers, which inhibits cancer cell proliferation by phosphorylating ERK and AKT, and also inhibits the interaction of RAS with guanine nucleotide exchange factors (GEFs). |
| Targets&IC50 | KRAS-SOS1:~0.5 nM, KRAS-mutant cell proliferation:0.17-2.9 nM |
| In vitro | Paluratide is a high-affinity cyclic peptide KRAS inhibitor that blocks KRAS/SOS1 interaction (IC₅₀ ≈ 0.5 nM). Paluratide inhibits proliferation in various KRAS-mutant cells (IC₅₀ = 0.17-2.9 nM) and reduces GTP-KRAS, pERK1/2, and pAKT levels significantly at 100 nM[1]. |
| In vivo | Paluratide shows 21% oral bioavailability in mice and, at 10 mg/kg daily, significantly suppresses tumor growth in KRAS-G12V xenograft models while reducing KRAS pathway activity, with no notable toxicity observed [1]. |
| Alias | LUNA18, LUNA 18 |
| Molecular Weight | 1437.68 |
| Formula | C73H105F5N12O12 |
| Cas No. | 2676177-63-0 |
| Smiles | O=C1C2(NC(=O)[C@]3(N(C(=O)[C@H](CCC4=CC(F)=C(C(F)(F)F)C(F)=C4)NC(=O)CN(C)C(=O)[C@H](CC5=CC=C(C)C=C5)N(CC)C(=O)[C@]6(N(C(=O)[C@H](C)N(C)C(=O)[C@]([C@H](CC)C)(NC(=O)[C@H](CC(C)C)N(C)C(=O)C[C@@H](C(N(C)C)=O)N(C)C(=O)[C@@H](N1C)C7CCCC7)[H])CC6)[H])CCC3)[H])CCCC2 |
Storage & Solubility Information
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (55.65 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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