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Paluratide

🥰Excellent
Catalog No. T79673Cas No. 2676177-63-0
Alias LUNA18, LUNA 18

Paluratide (LUNA18) is a reversible cyclic peptide KRAS inhibitor with the advantages of oral availability and cell permeability for the treatment of kras-mutant cancers, which inhibits cancer cell proliferation by phosphorylating ERK and AKT, and also inhibits the interaction of RAS with guanine nucleotide exchange factors (GEFs).

Paluratide

Paluratide

🥰Excellent
Purity: 98.70%
Catalog No. T79673Alias LUNA18, LUNA 18Cas No. 2676177-63-0
Paluratide (LUNA18) is a reversible cyclic peptide KRAS inhibitor with the advantages of oral availability and cell permeability for the treatment of kras-mutant cancers, which inhibits cancer cell proliferation by phosphorylating ERK and AKT, and also inhibits the interaction of RAS with guanine nucleotide exchange factors (GEFs).
Pack SizePriceAvailabilityQuantity
1 mg$1,180In Stock
5 mg$3,280In Stock
10 mg$4,450In Stock
25 mg$6,620In Stock
50 mg$8,930In Stock
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Purity:98.70%
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Product Introduction

Bioactivity
Description
Paluratide (LUNA18) is a reversible cyclic peptide KRAS inhibitor with the advantages of oral availability and cell permeability for the treatment of kras-mutant cancers, which inhibits cancer cell proliferation by phosphorylating ERK and AKT, and also inhibits the interaction of RAS with guanine nucleotide exchange factors (GEFs).
Targets&IC50
KRAS-mutant cell proliferation:0.17-2.9 nM, KRAS-SOS1:~0.5 nM
In vitro
Paluratide is a high-affinity cyclic peptide KRAS inhibitor that blocks KRAS/SOS1 interaction (IC₅₀ ≈ 0.5 nM). Paluratide inhibits proliferation in various KRAS-mutant cells (IC₅₀ = 0.17-2.9 nM) and reduces GTP-KRAS, pERK1/2, and pAKT levels significantly at 100 nM[1].
In vivo
Paluratide shows 21% oral bioavailability in mice and, at 10 mg/kg daily, significantly suppresses tumor growth in KRAS-G12V xenograft models while reducing KRAS pathway activity, with no notable toxicity observed [1].
AliasLUNA18, LUNA 18
Chemical Properties
Molecular Weight1437.68
FormulaC73H105F5N12O12
Cas No.2676177-63-0
SmilesO=C1C2(NC(=O)[C@]3(N(C(=O)[C@H](CCC4=CC(F)=C(C(F)(F)F)C(F)=C4)NC(=O)CN(C)C(=O)[C@H](CC5=CC=C(C)C=C5)N(CC)C(=O)[C@]6(N(C(=O)[C@H](C)N(C)C(=O)[C@]([C@H](CC)C)(NC(=O)[C@H](CC(C)C)N(C)C(=O)C[C@@H](C(N(C)C)=O)N(C)C(=O)[C@@H](N1C)C7CCCC7)[H])CC6)[H])CCC3)[H])CCCC2
Storage & Solubility Information
Storagekeep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (55.65 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.6956 mL3.4778 mL6.9557 mL34.7783 mL
5 mM0.1391 mL0.6956 mL1.3911 mL6.9557 mL
10 mM0.0696 mL0.3478 mL0.6956 mL3.4778 mL
20 mM0.0348 mL0.1739 mL0.3478 mL1.7389 mL
50 mM0.0139 mL0.0696 mL0.1391 mL0.6956 mL

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