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Anti-IL-1 beta Polyclonal Antibody 2 is a Rabbit antibody targeting IL-1 beta. Anti-IL-1 beta Polyclonal Antibody 2 can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $220 | 7-10 days | |
| 100 μL | $374 | 7-10 days | |
| 200 μL | $529 | 7-10 days |
| Description | Anti-IL-1 beta Polyclonal Antibody 2 is a Rabbit antibody targeting IL-1 beta. Anti-IL-1 beta Polyclonal Antibody 2 can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Rat,Bee) |
| Verified Activity | 1. Sample: Kidney (Mouse) Lysate at 40 μg Primary: Anti-IL-1 Beta (TMAB-00933) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 17 kDa Observed band size: 16 kDa 2. Sample: Hemocyte (Mouse) Lysate at 40 μg Primary: Anti-IL-1 Beta (TMAB-00933) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 17 kDa Observed band size: 30 kDa ![]() ![]() |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| Concentration | 1 mg/mL |
| Research Background | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated synthetic peptide: human IL-1 Beta |
| Antigen Species | Human |
| Gene Name | IL1B |
| Gene ID | |
| Protein Name | Interleukin-1 beta |
| Uniprot ID | |
| Biology Area | Inflammatory mediators,Interleukins,Obesity,SARS Coronavirus |
| Function | Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. |
| Molecular Weight | Theoretical: 17/32 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |

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