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Iluzanebart
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Catalog No. T82077Cas No. 2733621-19-5
Iluzanebart, a human monoclonal IgG1 antibody, functions as an agonist antibody for human TREM2 (hTREM2), thereby enhancing the survival and overall function of microglia through the activation of the TREM2 signaling pathway. Iluzanebart provides compensation for the loss of CSF1R function, and it can be employed as a research agent for adult-onset leukoencephalopathy associated with CSF1R (colony stimulating factor 1 receptor) (CSF1R-ALSP), thereby providing opportunities to model microglial dysfunction in neurodegenerative disorders.
Iluzanebart
Iluzanebart
😃Good
Purity: 95%
Catalog No. T82077Cas No. 2733621-19-5
Iluzanebart, a human monoclonal IgG1 antibody, functions as an agonist antibody for human TREM2 (hTREM2), thereby enhancing the survival and overall function of microglia through the activation of the TREM2 signaling pathway. Iluzanebart provides compensation for the loss of CSF1R function, and it can be employed as a research agent for adult-onset leukoencephalopathy associated with CSF1R (colony stimulating factor 1 receptor) (CSF1R-ALSP), thereby providing opportunities to model microglial dysfunction in neurodegenerative disorders.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $247 | - | In Stock | |
| 5 mg | $622 | - | In Stock | |
| 10 mg | $996 | - | In Stock | |
| 25 mg | $1,470 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:97.7% (SDS-PAGE); 98.3% (SEC-HPLC)
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| Description | Iluzanebart, a human monoclonal IgG1 antibody, functions as an agonist antibody for human TREM2 (hTREM2), thereby enhancing the survival and overall function of microglia through the activation of the TREM2 signaling pathway. Iluzanebart provides compensation for the loss of CSF1R function, and it can be employed as a research agent for adult-onset leukoencephalopathy associated with CSF1R (colony stimulating factor 1 receptor) (CSF1R-ALSP), thereby providing opportunities to model microglial dysfunction in neurodegenerative disorders. |
| In vitro | Methods: hMDM and iMGL cells were treated with Iluzanebart (10 µg/mL, 48-96 h), and cell viability was measured using CellTiter Glo. Results: Iluzanebart significantly protected cells from PLX5622-induced decline in cell viability. [1] |
| In vivo | Methods: Iluzanebart (1-200 mg/kg, single dose) was administered intraperitoneally to hTREM2-CV mice. The effects of Iluzanebart on microglial gene expression and proliferation were evaluated through RNA sequencing and cellular analysis. Results: Iluzanebart increased microglial proliferation and CSF1R surface levels in the mouse brain, with significant elevation in specific chemokine levels (such as IP10 and MIP1α). [1] |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | TREM2 |
| Molecular Weight | 144.90 kDa |
| Cas No. | 2733621-19-5 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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