B7-H4 Protein, Human, Recombinant (His & Avi)

B7-H4, also known as B7x and B7S1, is a 50-80 kDa glycosylated member of the B7 family of immunomodulatory proteins.B7-H4 is up-regulated in several carcinomas in correlation with tumor progression and metastasis. A soluble form of B7-H4 is elevated in the serum of ovarian cancer, renal cell carcinoma, and rheumatoid arthritis patients, also in correlation with advanced disease status .

Pack Size	Availability	Price/USD
100 μg	5 days	$ 302.00
500 μg	5 days	$ 1,210.00
1 mg	5 days	$ 2,010.00

Pack Size

Availability

Price/USD

Quantity

100 μg

5 days

$ 302.00

500 μg

5 days

$ 1,210.00

1 mg

5 days

$ 2,010.00

Description

Species	Human
Expression System	HEK293
Tag	C-His-Avi
Accession Number	Q7Z7D3-1
Synonyms	B7H4, B7x, VTCN1, PRO1291, B7S1, B7h.5, FLJ22418, B7-H4
Construction	Recombinant Human B7-H4 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Phe29-Ala258.[Accession \|Q7Z7D3-1]
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight	The protein has a predicted MW of 28.2 kDa. Due to glycosylation, the protein migrates to 52-68 kDa based on Tris-Bis PAGE result.

Endotoxin	Less than 1EU per μg by the LAL method.
Formulation	Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability & Storage	-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	B7-H4, also known as B7x and B7S1, is a 50-80 kDa glycosylated member of the B7 family of immunomodulatory proteins.B7-H4 is up-regulated in several carcinomas in correlation with tumor progression and metastasis. A soluble form of B7-H4 is elevated in the serum of ovarian cancer, renal cell carcinoma, and rheumatoid arthritis patients, also in correlation with advanced disease status .