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3,7,4'-Trihydroxyflavone

Name: 3,7,4'-Trihydroxyflavone
Brand: TargetMol
SKU: TN2143
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN2143Cas No. 2034-65-3

Alias Resokaempferol, 5-Deoxykampferol

3,7,4'-Trihydroxyflavone(5-Deoxykampferol) is a DNA-breaking flavonoid isolated from rosewood heartwood. It inhibits osteoclast differentiation, actin ring formation, and bone resorption in RAW 264.7 cells and bone marrow macrophages induced by NF-κB ligand (RANKL) receptor activators.

3,7,4'-Trihydroxyflavone

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Purity: 99.15%

Catalog No. TN2143Alias Resokaempferol, 5-DeoxykampferolCas No. 2034-65-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	In Stock	In Stock
5 mg	$156	In Stock	In Stock
10 mg	$228	In Stock	In Stock
25 mg	$463	In Stock	In Stock
50 mg	$666	In Stock	In Stock
100 mg	$928	-	In Stock
200 mg	$1,250	-	In Stock
1 mL x 10 mM (in DMSO)	$245	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.15%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

3,7,4'-Trihydroxyflavone AI Summary

3,7,4'-Trihydroxyflavone exhibits versatile bioactivity, including notable antioxidant properties and kinase inhibition capabilities. It scavenges DPPH radicals with an IC25 of 4.1 μM and effectively inhibits superoxide production at an IC25 of 48.0 μM. In BALB/c mouse BM cells, it inhibits ROS production with an IC25 of 23.0 μM. Furthermore, it potently inhibits PIM1 kinase with an IC50 of 0.01 μM and bovine thymus p56-LCK protein tyrosine kinase with an IC50 of 5.0 μg/mL. Additionally, 3,7,4'-Trihydroxyflavone demonstrates inhibitory effects on the formation of carboxymethylated kappa-casein fibrils and various other biological targets, including Menin-MLL interaction, ERK signaling pathway, and enzymes like HSD17B4, JMJD2E, and Caspases. It is cytotoxic to cancer cells harboring p53 mutations and affects lipid storage modulation. Particularly potent against prostate cancer, it inhibits PSA expression and androgen receptor activity in 22Rv1 cells while suppressing cell proliferation with an IC50 of 30200.0 nM. In enzymatic assays, 3,7,4'-Trihydroxyflavone decreases estrone levels by 101.7% by inhibiting human aromatase activity. It also inhibits the Cav1.2 calcium current in rat artery myocytes with an IC50 of 27500.0 nM. Against parasites, it shows moderate activity against Trypanosoma brucei PTR1 and antitrypanosomal activity against Trypanosoma brucei bloodstream forms (EC50 of 4290.0 nM), with a favorable cytotoxicity profile (NOAEL of 20.0 μM in human THP1 cells). Lastly, 3,7,4'-Trihydroxyflavone exhibits inhibition of human liver FBP1 at 200 μM with less than 20% activity relative to the control. Collectively, these multi-faceted bioactivities underline the compound's potential for various therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	3,7,4'-Trihydroxyflavone(5-Deoxykampferol) is a DNA-breaking flavonoid isolated from rosewood heartwood. It inhibits osteoclast differentiation, actin ring formation, and bone resorption in RAW 264.7 cells and bone marrow macrophages induced by NF-κB ligand (RANKL) receptor activators.
Synonyms	Resokaempferol, 5-Deoxykampferol

Chemical Properties

Molecular Weight	270.24
Formula	C₁₅H₁₀O₅
Cas No.	2034-65-3
Smiles	Oc1ccc(cc1)-c1oc2cc(O)ccc2c(=O)c1O
Relative Density.	1.579g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (333.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (12.21 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7004 mL	18.5021 mL	37.0041 mL	185.0207 mL
5 mM	0.7401 mL	3.7004 mL	7.4008 mL	37.0041 mL
10 mM	0.3700 mL	1.8502 mL	3.7004 mL	18.5021 mL
20 mM	0.1850 mL	0.9251 mL	1.8502 mL	9.2510 mL
50 mM	0.0740 mL	0.3700 mL	0.7401 mL	3.7004 mL
100 mM	0.0370 mL	0.1850 mL	0.3700 mL	1.8502 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc