Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NDNA3 (compound 14) selectively inhibits Hsp90α with an IC50 of 0.51 μM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10A cells, with IC50 values of 12.66 μM and 11.72 μM respectively. It stabilizes hERG channel maturation without eliciting a heat shock response or degrading Hsp90α-dependent client proteins [1].
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Description | NDNA3 (compound 14) selectively inhibits Hsp90α with an IC50 of 0.51 μM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10A cells, with IC50 values of 12.66 μM and 11.72 μM respectively. It stabilizes hERG channel maturation without eliciting a heat shock response or degrading Hsp90α-dependent client proteins [1]. |
Molecular Weight | 476.63 |
Formula | C28H32N2O3S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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NDNA3 Cytoskeletal Signaling Metabolism HSP inhibitor inhibit