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NVOC cage-TMP-Halo

Name: NVOC cage-TMP-Halo
Brand: TargetMol
SKU: T78534
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78534Cas No. 2137894-98-3

NVOC cage-TMP-Halo is a cell-permeable, photoactivatable protein dimerization inducer that enables rapid, reversible, and spatially controlled manipulation of protein localization in living cells, offering a powerful optochemical approach for studying dynamic cellular processes, signal transduction, and real-time protein function with high temporal precision.

NVOC cage-TMP-Halo

😃Good

Catalog No. T78534Cas No. 2137894-98-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$58	-	In Stock
5 mg	$139	-	In Stock
10 mg	$222	-	In Stock
25 mg	$416	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description	NVOC cage-TMP-Halo is a cell-permeable, photoactivatable protein dimerization inducer that enables rapid, reversible, and spatially controlled manipulation of protein localization in living cells, offering a powerful optochemical approach for studying dynamic cellular processes, signal transduction, and real-time protein function with high temporal precision.
In vitro	NVOC cage-TMP-Halo (20μM, for 15, 30, and 60 minutes) demonstrated precise spatial manipulation of protein localization in HeLa cells [1]. When applied to HeLa cells expressing CENPB-GFP-Haloenzyme and mCherry-eDHFR, NVOC cage-TMP-Halo (20μM, 60 min) significantly recruited mCherry-eDHFR to the centromere with a half-time (t1/2) of 15 seconds [1].

Chemical Properties

Molecular Weight	878.37
Formula	C₄₀H₅₆ClN₇O₁₃
Cas No.	2137894-98-3
Smiles	O=C(NC1=NC=C(CC2=CC(OC)=C(C(OC)=C2)OCCCNC(CCC(NCCOCCOCCCCCCCl)=O)=O)C(N)=N1)OCC3=CC(OC)=C(C=C3[N+]([O-])=O)OC

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (136.62 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1385 mL	5.6924 mL	11.3847 mL	56.9236 mL
5 mM	0.2277 mL	1.1385 mL	2.2769 mL	11.3847 mL
10 mM	0.1138 mL	0.5692 mL	1.1385 mL	5.6924 mL
20 mM	0.0569 mL	0.2846 mL	0.5692 mL	2.8462 mL
50 mM	0.0228 mL	0.1138 mL	0.2277 mL	1.1385 mL
100 mM	0.0114 mL	0.0569 mL	0.1138 mL	0.5692 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc