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Complex 3

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Catalog No. T205594Cas No. 2480150-28-3

Complex 3 is a fluorescent dithiocarbamate-copper complex exhibiting anticancer properties, specifically targeting mitochondria. It has excitation/emission maxima at 455-495/535 nm. Complex 3 inhibits the growth of pancreatic cancer cells BxPC-3, AsPC-1, PANC-1, and WI38, with IC50 values of 0.74, 0.41, 0.62, and 2.06 µM, respectively. In AsPC-1 cells, it induces lipid peroxidation, mitochondrial fragmentation and constriction, apoptosis, and cytokine-cytokine receptor interaction dysfunction. Furthermore, Complex 3 reduces tumor volume and induces apoptosis within tumors in AsPC-1 mouse xenograft models.

Complex 3

Complex 3

😃Good
Catalog No. T205594Cas No. 2480150-28-3
Complex 3 is a fluorescent dithiocarbamate-copper complex exhibiting anticancer properties, specifically targeting mitochondria. It has excitation/emission maxima at 455-495/535 nm. Complex 3 inhibits the growth of pancreatic cancer cells BxPC-3, AsPC-1, PANC-1, and WI38, with IC50 values of 0.74, 0.41, 0.62, and 2.06 µM, respectively. In AsPC-1 cells, it induces lipid peroxidation, mitochondrial fragmentation and constriction, apoptosis, and cytokine-cytokine receptor interaction dysfunction. Furthermore, Complex 3 reduces tumor volume and induces apoptosis within tumors in AsPC-1 mouse xenograft models.
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Product Introduction

Bioactivity
Description
Complex 3 is a fluorescent dithiocarbamate-copper complex exhibiting anticancer properties, specifically targeting mitochondria. It has excitation/emission maxima at 455-495/535 nm. Complex 3 inhibits the growth of pancreatic cancer cells BxPC-3, AsPC-1, PANC-1, and WI38, with IC50 values of 0.74, 0.41, 0.62, and 2.06 µM, respectively. In AsPC-1 cells, it induces lipid peroxidation, mitochondrial fragmentation and constriction, apoptosis, and cytokine-cytokine receptor interaction dysfunction. Furthermore, Complex 3 reduces tumor volume and induces apoptosis within tumors in AsPC-1 mouse xenograft models.
Chemical Properties
Molecular Weight1005.12
FormulaC26H22Br3Cu3N8S4
Cas No.2480150-28-3
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature.

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