CD19 Protein, Human, Recombinant (His)

Catalog No. TMPY-01949 Copy Product Info

CD19 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.6 kDa and the accession number is P15391-1.

CD19 Protein, Human, Recombinant (His)

Catalog No. TMPY-01949

Copy Product Info

CD19 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.6 kDa and the accession number is P15391-1.

Pack Size	Price	USA Stock	Global Stock
5 μg	$62	-	In Stock
10 μg	$98	7-10 days	7-10 days
20 μg	$159	7-10 days	7-10 days
50 μg	$315	-	In Stock
100 μg	$558	7-10 days	7-10 days
200 μg	$983	7-10 days	7-10 days
500 μg	$2,080	7-10 days	7-10 days

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For In stock only · Estimated delivery:USA Stock (1-2 days) Global Stock (5-7 days)

For research use only—not for human use. No sales to individuals. Use as intended only.

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COA User Guide of Recombinant Proteins

Product Information

Biological Activity	Immobilized Recombinant Human CD19 / Leu-12 Protein (ECD,His Tag) at 2 μg/mL (100 μL/well) can bind Monoclonal Anti-Human CD19 Antibody (IgG1) , the EC50 is 8-24 ng/mL.
Description	CD19 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.6 kDa and the accession number is P15391-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	P15391-1
Synonyms	CVID3,CD19 molecule,B4
Construction	A DNA sequence encoding the human CD19 (P15391-1) extracellular domain (Met1-Lys291) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Pro 20
Protein Purity	> 90 % as determined by SDS-PAGE
Molecular Weight	31.6 kDa (predicted); 47 kDa (reducing condition, due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Research Background	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 19 (CD19) is a member of CD system. CD19 is a cell surface molecule that assembles with the antigen receptor of B-cells. This results in a descent in the threshold for antigen receptor-dependent stimulation. A simplified view holds that the ability of B-cells to respond to the various antigens in a specific and sensitive manner is achieved in the presence of low-affinity antigen receptors. CD19 primarily acts as a B-cell co-receptor in conjunction with CD21 and CD81. The formation of the receptor complex is induced by antigen and CD19, induced by exogenous antigen, has been found cytoplasmic tail phosphorylated and bind to sIg.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy