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Murepavadin TFA

Name: Murepavadin TFA
Brand: TargetMol
SKU: T75996
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T75996Cas No. 3053070-05-3

Alias POL7080 TFA, POL 7080 TFA, Murepavadin TFA

Murepavadin TFA is a highly potent 14–amino acid cyclic peptide antibiotic that exhibits strong and specific antibacterial activity against Pseudomonas aeruginosa, with MIC50 and MIC90 values both measured at 0.12 mg/L, functioning through targeted interaction with the lipopolysaccharide transport protein D, and serving as a valuable research compound for studying bacterial resistance mechanisms, antimicrobial specificity, and novel antibiotic development strategies.

Murepavadin TFA

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Purity: 99.99%

Catalog No. T75996Alias POL7080 TFA, POL 7080 TFA, Murepavadin TFACas No. 3053070-05-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	-	In Stock
5 mg	$289	-	In Stock
10 mg	$455	-	In Stock
25 mg	$889	-	In Stock
50 mg	$1,360	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.99%

Appearance:Solid

Color:White

Resource Download

COA MS HPLC

Product Introduction

Bioactivity

Description	Murepavadin TFA is a highly potent 14–amino acid cyclic peptide antibiotic that exhibits strong and specific antibacterial activity against Pseudomonas aeruginosa, with MIC50 and MIC90 values both measured at 0.12 mg/L, functioning through targeted interaction with the lipopolysaccharide transport protein D, and serving as a valuable research compound for studying bacterial resistance mechanisms, antimicrobial specificity, and novel antibiotic development strategies.
In vivo	Method: Murepavadin TFA was administered subcutaneously at doses ranging from 0 to 100 mg/kg in preclinical infection models using XDR bacterial isolates. Result: Murepavadin TFA demonstrated antibacterial activity in preclinical animal infection models[1].
Synonyms	POL7080 TFA, POL 7080 TFA, Murepavadin TFA

Chemical Properties

Molecular Weight	1667.83
Formula	C₇₃H₁₁₂N₂₂O₁₆.C₂HF₃O₂
Cas No.	3053070-05-3
Smiles	CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2CCC[C@@H]2C(=O)N3CCC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC4=CNC5=CC=CC=C54)[C@@H](C)O)CO)C)CCN)CCN)CC6=CNC7=CC=CC=C76)CCN)CCN)CCCN)CCN.C(=O)(C(F)(F)F)O
Sequence	Cyclo[Ala-Ser-dPro-Pro-Thr-Trp-Ile-Dab-Orn-dDab-Dab-Trp-Dab-Dab].CH3CO2H
Sequence Short	Cyclo(AS-{d-Pro}-PTWI-{Dab}-{Orn}-{d-Dab}-{Dab}-W-{Dab}-{Dab})

Storage & Solubility Information

Storage

keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 40.00 mg/mL (23.98 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.5996 mL	2.9979 mL	5.9958 mL	29.9791 mL
5 mM	0.1199 mL	0.5996 mL	1.1992 mL	5.9958 mL
10 mM	0.0600 mL	0.2998 mL	0.5996 mL	2.9979 mL
20 mM	0.0300 mL	0.1499 mL	0.2998 mL	1.4990 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc