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Murepavadin TFA

😃Good
Catalog No. T75996Cas No. 3053070-05-3
Alias POL7080 TFA, POL 7080 TFA, Murepavadin TFA

Murepavadin TFA is a highly potent 14–amino acid cyclic peptide antibiotic that exhibits strong and specific antibacterial activity against Pseudomonas aeruginosa, with MIC50 and MIC90 values both measured at 0.12 mg/L, functioning through targeted interaction with the lipopolysaccharide transport protein D, and serving as a valuable research compound for studying bacterial resistance mechanisms, antimicrobial specificity, and novel antibiotic development strategies.

Murepavadin TFA
Other Forms of Murepavadin TFA:

Murepavadin TFA

😃Good
Purity: 99.99%
Catalog No. T75996Alias POL7080 TFA, POL 7080 TFA, Murepavadin TFACas No. 3053070-05-3
Murepavadin TFA is a highly potent 14–amino acid cyclic peptide antibiotic that exhibits strong and specific antibacterial activity against Pseudomonas aeruginosa, with MIC50 and MIC90 values both measured at 0.12 mg/L, functioning through targeted interaction with the lipopolysaccharide transport protein D, and serving as a valuable research compound for studying bacterial resistance mechanisms, antimicrobial specificity, and novel antibiotic development strategies.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$117-In Stock
5 mg$289-In Stock
10 mg$455-In Stock
25 mg$889-In Stock
50 mg$1,360-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.99%
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Product Introduction

Bioactivity
Description
Murepavadin TFA is a highly potent 14–amino acid cyclic peptide antibiotic that exhibits strong and specific antibacterial activity against Pseudomonas aeruginosa, with MIC50 and MIC90 values both measured at 0.12 mg/L, functioning through targeted interaction with the lipopolysaccharide transport protein D, and serving as a valuable research compound for studying bacterial resistance mechanisms, antimicrobial specificity, and novel antibiotic development strategies.
In vivo
Method: Murepavadin TFA was administered subcutaneously at doses ranging from 0 to 100 mg/kg in preclinical infection models using XDR bacterial isolates.
Result: Murepavadin TFA demonstrated antibacterial activity in preclinical animal infection models[1].
SynonymsPOL7080 TFA, POL 7080 TFA, Murepavadin TFA
Chemical Properties
Molecular Weight1667.83
FormulaC73H112N22O16.C2HF3O2
Cas No.3053070-05-3
SmilesCC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2CCC[C@@H]2C(=O)N3CCC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC4=CNC5=CC=CC=C54)[C@@H](C)O)CO)C)CCN)CCN)CC6=CNC7=CC=CC=C76)CCN)CCN)CCCN)CCN.C(=O)(C(F)(F)F)O
ColorWhite
AppearanceSolid
SequenceCyclo(Ala-Ser-{d-Pro}-Pro-Thr-Trp-Ile-{Dab}-{Orn}-{d-Dab}-{Dab}-Trp-{Dab}-{Dab})
Sequence ShortCyclo(AS-{d-Pro}-PTWI-{Dab}-{Orn}-{d-Dab}-{Dab}-W-{Dab}-{Dab})
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 40.00 mg/mL (23.98 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM0.5996 mL2.9979 mL5.9958 mL29.9791 mL
5 mM0.1199 mL0.5996 mL1.1992 mL5.9958 mL
10 mM0.0600 mL0.2998 mL0.5996 mL2.9979 mL
20 mM0.0300 mL0.1499 mL0.2998 mL1.4990 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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1 Enter information below:
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2 Enter the in vivo formulation:
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