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HP210

Name: HP210
Brand: TargetMol
SKU: T78073
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: HP-210) Copy Product Info

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Synonyms: HP-210

Catalog No. T78073 Copy Product Info

Purity: 99.37%

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HP210 is a selective glucocorticoid receptor modulator (SGRM) that significantly downregulates the mRNA expression levels of IL-1β and IL-6, making it a promising candidate for research into inflammation-related diseases.

Cas No. 728039-52-9

Pack Size	Price	USA Stock	Global Stock
1 mg	$39	-	In Stock
5 mg	$89	-	In Stock
10 mg	$147	-	In Stock
25 mg	$303	-	In Stock
1 mL x 10 mM (in DMSO)	$98	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.37%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	HP210 is a selective glucocorticoid receptor modulator (SGRM) that significantly downregulates the mRNA expression levels of IL-1β and IL-6, making it a promising candidate for research into inflammation-related diseases.
In vitro	Methods: Rat airway organoids were first treated with 10 μg/mL LPS for 5 days to establish a COPD model, followed by treatment with 10 μM R-HP210 for 5 days; MUC5AC was stained using immunofluorescence, and the proportion of goblet cells was quantified via high-content analysis. Results: R-HP210 significantly reduced the number of LPS-induced MUC5AC⁺ goblet cells and effectively inhibited excessive mucus secretion. [1]
Synonyms	HP-210

Chemical Properties

Molecular Weight	421.54
Formula	C₂₂H₁₉N₃O₂S₂
Cas No.	728039-52-9
Smiles	O=C(NC(C=1C=CC=CC1)C)C2=CC=C(C=C2)CN3C(=O)C=4SC=CC4NC3=S

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (237.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3723 mL	11.8613 mL	23.7225 mL	118.6127 mL
5 mM	0.4745 mL	2.3723 mL	4.7445 mL	23.7225 mL
10 mM	0.2372 mL	1.1861 mL	2.3723 mL	11.8613 mL
20 mM	0.1186 mL	0.5931 mL	1.1861 mL	5.9306 mL
50 mM	0.0474 mL	0.2372 mL	0.4745 mL	2.3723 mL
100 mM	0.0237 mL	0.1186 mL	0.2372 mL	1.1861 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc