AMX12006

Name: AMX12006
Brand: TargetMol
SKU: T78710
Rating: 4.5 (1 reviews)

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Catalog No. T78710Cas No. 2639775-01-0

AMX12006, a potent and selective EP4 antagonist, exhibits cytotoxic and antitumor activity, demonstrating oral activity with an IC50 of 4.3 nM [1].

AMX12006

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Catalog No. T78710Cas No. 2639775-01-0

AMX12006, a potent and selective EP4 antagonist, exhibits cytotoxic and antitumor activity, demonstrating oral activity with an IC50 of 4.3 nM [1].

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$198	35 days	35 days
5 mg	$917	35 days	35 days
10 mg	$1,620	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	AMX12006, a potent and selective EP4 antagonist, exhibits cytotoxic and antitumor activity, demonstrating oral activity with an IC50 of 4.3 nM [1].
Targets&IC50	EP4 (human):4.3 nM
In vitro	AMX12006, at concentrations ranging from 0 to 100 µM, exhibits cytotoxic effects with IC50 values of 46.73 µM for MCF-7, 79.47 µM for 4T1, over 100 µM for HCA-7, 41.39 µM for CT-26 WT, and over 100 µM for LLC cells [1].
In vivo	AMX12006, administered orally at doses of 75 and 150 mg/kg once daily for 11 days, demonstrated dose-dependent antitumor activity [1].

Chemical Properties

Molecular Weight	481.47
Formula	C₂₆H₂₂F₃N₃O₃
Cas No.	2639775-01-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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