AMX12006

Name: AMX12006
Brand: TargetMol
SKU: T78710
Rating: 4.5 (1 reviews)

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Catalog No. T78710Cas No. 2639775-01-0

AMX12006, a potent and selective EP4 antagonist, exhibits cytotoxic and antitumor activity, demonstrating oral activity with an IC50 of 4.3 nM [1].

AMX12006

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Catalog No. T78710Cas No. 2639775-01-0

AMX12006, a potent and selective EP4 antagonist, exhibits cytotoxic and antitumor activity, demonstrating oral activity with an IC50 of 4.3 nM [1].

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$198	35 days	35 days
5 mg	$917	35 days	35 days
10 mg	$1,620	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	AMX12006, a potent and selective EP4 antagonist, exhibits cytotoxic and antitumor activity, demonstrating oral activity with an IC50 of 4.3 nM [1].
Targets&IC50	EP4 (human):4.3 nM
In vitro	AMX12006, at concentrations ranging from 0 to 100 µM, exhibits cytotoxic effects with IC50 values of 46.73 µM for MCF-7, 79.47 µM for 4T1, over 100 µM for HCA-7, 41.39 µM for CT-26 WT, and over 100 µM for LLC cells [1].
In vivo	AMX12006, administered orally at doses of 75 and 150 mg/kg once daily for 11 days, demonstrated dose-dependent antitumor activity [1].

Chemical Properties

Molecular Weight	481.47
Formula	C₂₆H₂₂F₃N₃O₃
Cas No.	2639775-01-0
Smiles	N(C=1C=2C(N(C)C1C(N[C@@H](C)C3=CC=C(C(O)=O)C=C3)=O)=CC=CC2)C4=CC(C(F)(F)F)=CC=C4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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