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8-Chloroadenosine-5'-triphosphate sodium

Catalog No. T83786 CAS 793671-47-3

Synonyms: 8-chloro ATP

8-Chloroadenosine-5’-triphosphate (8-chloro ATP), a potent metabolite of the anticancer agent 8-chloro cyclic AMP (cAMP) and a nucleotide derivative, is produced through the biotransformation of 8-chloro cAMP into 8-chloroadenosine, followed by mono- and diphosphate intermediates. Accumulating for up to 12 hours after the administration of 8-chloro cAMP or 8-chloroadenosine, 8-chloro ATP inhibits cell growth, diminishes endogenous ATP levels, and reduces RNA synthesis without affecting DNA synthesis in multiple myeloma cells derived from patients. Moreover, it obstructs topoisomerase II-α-mediated relaxation of supercoiled pUC19 DNA at concentrations ranging from 1.5 to 8 mM and decreases topoisomerase II-α-enhanced ATP hydrolysis by 50% at a concentration of 1 mM in K562 human myelocytic leukemia cells.

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8-Chloroadenosine-5'-triphosphate sodium Chemical Structure

8-Chloroadenosine-5'-triphosphate sodium, CAS 793671-47-3

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2700 μg	35 days	$ 635.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	8-chloro ATP
Molecular Weight	629.55
Formula	C10H11ClN5O13P3.4Na
CAS No.	793671-47-3

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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H2O: Soluble

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Keywords

8-Chloroadenosine-5'-triphosphate sodium 793671-47-3 8-chloro ATP inhibitor inhibit

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