Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Anti-inflammatory agent 17 an orally active anti-inflammatory agent, demonstrates potent efficacy in inhibiting the release of IL-6 and TNF-α without causing cytotoxicity in in vitro experiments. Furthermore, in vivo studies confirm its anti-inflammatory activity. Given its attributes, Compound 17 holds promise for investigating Acute lung injury (ALI) [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Anti-inflammatory agent 17 an orally active anti-inflammatory agent, demonstrates potent efficacy in inhibiting the release of IL-6 and TNF-α without causing cytotoxicity in in vitro experiments. Furthermore, in vivo studies confirm its anti-inflammatory activity. Given its attributes, Compound 17 holds promise for investigating Acute lung injury (ALI) [1]. |
In vitro | Anti-inflammatory agent 17 (compound 5b) (10 μM; 24 h) displays no toxicity in J774a.1 cells [1]. Anti-inflammatory agent 17 (1.25, 2.5, 5, 10 μM; 2 h) inhibits the production of IL-6 (IC 50 =8.254 μM) and TNF-α (IC 50 =2.576 μM) in J774a.1 cells in a dose-dependent manner [1]. Cell Viability Assay [1] Cell Line: J774a.1 cells Concentration: 10 μM Incubation Time: 24 h Result: Displayed no toxicity in J774a.1 cells. Immunofluorescence [1] Cell Line: J774A.1 cells Concentration: 1.25, 2.5, 5, 10 μM Incubation Time: 2 h Result: Inhibited the production of IL-6 (IC 50 =8.254 μM) and TNF-α (IC 50 =2.576 μM) in J774a.1 cells in a dose-dependent manner. |
In vivo | The anti-inflammatory agent 17, when administered intragastrically at a dosage of 20 mg/kg, has demonstrated a protective effect against lipopolysaccharide (LPS)-induced acute lung injury (ALI) in C57/BL6 mice [1]. |
Molecular Weight | 357.4 |
Formula | C20H23NO5 |
CAS No. | 2763226-84-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Anti-inflammatory agent 17 2763226-84-0 inhibitor inhibit