NKG2D/CD314 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 20-30 KDa and the accession number is O54709.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 μg | 5 days | $ 105.00 | |
50 μg | 5 days | $ 321.00 | |
500 μg | 5 days | $ 1,600.00 | |
1 mg | 5 days | $ 2,400.00 |
Description | NKG2D/CD314 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 20-30 KDa and the accession number is O54709. |
Species | Mouse |
Expression System | Human Cells |
Tag | N-6His |
Accession Number | O54709 |
Synonyms | KLR, NKG2-D type II integral membrane protein, CD314, NKG2-D-activating NK receptor, KLRK1, CD314 antigen, member 1, NKG2-D, NK cell receptor D, Killer cell lectin-like receptor subfamily K member 1, killer cell lectin-like receptor subfamily K |
Amino Acid | Phe94 |
Construction | Recombinant Mouse NKG2-D type II Integral Membrane Protein is produced by our Mammalian expression system and the target gene encoding Phe94 - Val232 is expressed with a 6His tag at the N-terminus. |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
Molecular Weight | 20-30 KDa, reducing conditions |
Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
Reconstitution | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Stability & Storage |
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
Shipping |
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
Research Background | NKG2-D type II integral membrane protein (NKG2D) is a type II transmembrane glycoprotein which belongs to the CD94/NKG2 family. NKG2D is expressed on natural killer (NK) cells, CD8+ alpha-beta and gamma-delta T-cells. As an activating and costimulatory receptor, it involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. It provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. It stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. NKG2D participates in NK cell-mediated bone marrow graft rejection and survival of NK cells. It Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. |
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Please read the User Guide of Recombinant Proteins for more specific information.
NKG2D/CD314 Protein, Mouse, Recombinant (His) KLR KLRK 1 NKG2-D type II integral membrane protein CD314 CD-314 NKG2-D-activating NK receptor KLRK1 CD 314 CD314 antigen member 1 KLRK-1 NKG2-D NK cell receptor D Killer cell lectin-like receptor subfamily K member 1 killer cell lectin-like receptor subfamily K recombinant recombinant-proteins proteins protein