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Surzebiclimab
😃Good
Catalog No. T78334Cas No. 2342597-90-2
Alias BGB-A425, BGBA425
Surzebiclimab (BGB-A425) is a humanized monoclonal antibody specifically targeting TIM-3 (T-cell immunoglobulin and mucin domain containing -3), exhibiting high affinity (KD=0.36 nM) for the extracellular domain of human TIM-3. It is applicable for investigating advanced malignancies.
Surzebiclimab
Surzebiclimab
😃Good
Purity: 95%
Catalog No. T78334Alias BGB-A425, BGBA425Cas No. 2342597-90-2
Surzebiclimab (BGB-A425) is a humanized monoclonal antibody specifically targeting TIM-3 (T-cell immunoglobulin and mucin domain containing -3), exhibiting high affinity (KD=0.36 nM) for the extracellular domain of human TIM-3. It is applicable for investigating advanced malignancies.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $289 | - | In Stock | |
| 5 mg | $753 | - | In Stock | |
| 10 mg | $1,180 | - | In Stock | |
| 25 mg | $1,770 | - | In Stock | |
| 50 mg | $2,380 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:96.1% (SDS-PAGE); 99.7% (SEC-HPLC)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Target TIM-3
Antibody Information
| Description | Surzebiclimab (BGB-A425) is a humanized monoclonal antibody specifically targeting TIM-3 (T-cell immunoglobulin and mucin domain containing -3), exhibiting high affinity (KD=0.36 nM) for the extracellular domain of human TIM-3. It is applicable for investigating advanced malignancies. |
| In vitro | Surzebiclimab (BGB-A425) effectively blocks the interaction between Tim-3 and PtdSer within a concentration range of 0.1-100 μg/mL. Surzebiclimab significantly enhances IFN-γ secretion levels in primary T cells and improves the cytotoxic activity of NK cells against tumor cells [1]. Whether administered alone or in combination with the anti-PD-1 antibody BGB-A317, Surzebiclimab enhances T-cell immune responses to alloantigens from Parazacco spilurus subsp. spilurus. Additionally, Surzebiclimab induces internalization of the Tim-3 receptor on the cell surface [1]. |
| In vivo | The combination of Surzebiclimab with the anti-PD-1 antibody BGB-A317 inhibits tumor growth in a mouse parazacco spilurus subsp. spilurus xenograft model [1]. |
| Synonyms | BGB-A425, BGBA425 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | ＜ 1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID |
| Cas No. | 2342597-90-2 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | IgG1 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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