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Surzebiclimab
(Synonyms: BGB-A425, BGBA425) Copy Product Info
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Synonyms: BGB-A425, BGBA425
Catalog No. T78334 Copy Product Info
Purity: 95%
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Surzebiclimab (BGB-A425) is a humanized monoclonal antibody specifically targeting TIM-3 (T-cell immunoglobulin and mucin domain containing -3), exhibiting high affinity (KD=0.36 nM) for the extracellular domain of human TIM-3. It is applicable for investigating advanced malignancies.
Cas No. 2342597-90-2
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $289 | - | In Stock | |
| 5 mg | $753 | - | In Stock | |
| 10 mg | $1,180 | - | In Stock | |
| 25 mg | $1,770 | - | In Stock | |
| 50 mg | $2,380 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:96.1% (SDS-PAGE); 99.7% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
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Related Conjugates and Formulations
Antigen Details
Chemical Properties
Antibody Information
Storage & Solubility Information
| Description | Surzebiclimab (BGB-A425) is a humanized monoclonal antibody specifically targeting TIM-3 (T-cell immunoglobulin and mucin domain containing -3), exhibiting high affinity (KD=0.36 nM) for the extracellular domain of human TIM-3. It is applicable for investigating advanced malignancies. |
| In vitro | Surzebiclimab (BGB-A425) effectively blocks the interaction between Tim-3 and PtdSer within a concentration range of 0.1-100 μg/mL. Surzebiclimab significantly enhances IFN-γ secretion levels in primary T cells and improves the cytotoxic activity of NK cells against tumor cells [1]. Whether administered alone or in combination with the anti-PD-1 antibody BGB-A317, Surzebiclimab enhances T-cell immune responses to alloantigens from Parazacco spilurus subsp. spilurus. Additionally, Surzebiclimab induces internalization of the Tim-3 receptor on the cell surface [1]. |
| In vivo | The combination of Surzebiclimab with the anti-PD-1 antibody BGB-A317 inhibits tumor growth in a mouse parazacco spilurus subsp. spilurus xenograft model [1]. |
| Synonyms | BGB-A425, BGBA425 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | TIM-3/HAVCR2/CD366 |
| Molecular Weight | 144.80 kDa |
| Cas No. | 2342597-90-2 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Surzebiclimab chemical structure | Surzebiclimab in vivo | Surzebiclimab in vitro | Surzebiclimab molecular weight
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