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Tovetumab
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Catalog No. T76764Cas No. 1243266-04-7
Alias MEDI-575
Tovetumab (MEDI-575) is a fully human monoclonal antibody that exhibits high selectivity for platelet-derived growth factor receptor alpha (PDGFRα). it functions by specifically inhibiting PDGFRα signal transduction pathways, and it is currently being utilized in clinical research for the treatment of aggressive malignancies including glioblastoma and non-small cell lung cancer (NSCLC).
Tovetumab
Tovetumab
😃Good
Catalog No. T76764Alias MEDI-575Cas No. 1243266-04-7
Tovetumab (MEDI-575) is a fully human monoclonal antibody that exhibits high selectivity for platelet-derived growth factor receptor alpha (PDGFRα). it functions by specifically inhibiting PDGFRα signal transduction pathways, and it is currently being utilized in clinical research for the treatment of aggressive malignancies including glioblastoma and non-small cell lung cancer (NSCLC).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $298 | - | In Stock | |
| 5 mg | $788 | - | In Stock | |
| 10 mg | $1,230 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:95.4% (SDS-PAGE); 95.4% (SEC-HPLC)
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| Description | Tovetumab (MEDI-575) is a fully human monoclonal antibody that exhibits high selectivity for platelet-derived growth factor receptor alpha (PDGFRα). it functions by specifically inhibiting PDGFRα signal transduction pathways, and it is currently being utilized in clinical research for the treatment of aggressive malignancies including glioblastoma and non-small cell lung cancer (NSCLC). |
| In vitro | Methods: MG-63 cells were treated with Tovetumab (0.001-10 nM, 10 minutes), and the expression of related proteins was detected by Western blot. Results: Tovetumab was able to inhibit ligand-induced phosphorylation of human PDGFRα in MG-63 cells. [2] |
| In vivo | Methods: Tovetumab (0.6, 6.0, 60 mg/kg, intravenous injection) was administered to cynomolgus monkeys to observe its effects. Results: Tovetumab induced a more than 100-fold increase in circulating platelet-derived growth factor (PDGF-AA) levels in cynomolgus monkeys. [1] |
| Synonyms | MEDI-575 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | PDGFRA/CD140a |
| Molecular Weight | 144.78 kDa |
| Cas No. | 1243266-04-7 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG2 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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