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Tovetumab (Synonyms: MEDI-575)
Catalog No. T76764 Copy Product Info
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Tovetumab (MEDI-575) is a fully human monoclonal antibody that exhibits high selectivity for platelet-derived growth factor receptor alpha (PDGFRα). it functions by specifically inhibiting PDGFRα signal transduction pathways, and it is currently being utilized in clinical research for the treatment of aggressive malignancies including glioblastoma and non-small cell lung cancer (NSCLC).
Tovetumab
Copy Product Info🥰Excellent
Catalog No. T76764
Synonyms MEDI-575
Tovetumab (MEDI-575) is a fully human monoclonal antibody that exhibits high selectivity for platelet-derived growth factor receptor alpha (PDGFRα). it functions by specifically inhibiting PDGFRα signal transduction pathways, and it is currently being utilized in clinical research for the treatment of aggressive malignancies including glioblastoma and non-small cell lung cancer (NSCLC).
Tovetumab
Cas No. 1243266-04-7
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $298 | - | In Stock | |
| 5 mg | $788 | - | In Stock | |
| 10 mg | $1,230 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:95.4% (SDS-PAGE); 95.4% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Tovetumab (MEDI-575) is a fully human monoclonal antibody that exhibits high selectivity for platelet-derived growth factor receptor alpha (PDGFRα). it functions by specifically inhibiting PDGFRα signal transduction pathways, and it is currently being utilized in clinical research for the treatment of aggressive malignancies including glioblastoma and non-small cell lung cancer (NSCLC). |
| In vitro | Methods: MG-63 cells were treated with Tovetumab (0.001-10 nM, 10 minutes), and the expression of related proteins was detected by Western blot. Results: Tovetumab was able to inhibit ligand-induced phosphorylation of human PDGFRα in MG-63 cells. [2] |
| In vivo | Methods: Tovetumab (0.6, 6.0, 60 mg/kg, intravenous injection) was administered to cynomolgus monkeys to observe its effects. Results: Tovetumab induced a more than 100-fold increase in circulating platelet-derived growth factor (PDGF-AA) levels in cynomolgus monkeys. [1] |
| Synonyms | MEDI-575 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | PDGFRA/CD140a |
| Molecular Weight | 144.78 kDa |
| Cas No. | 1243266-04-7 |
| Isotype | Human IgG2 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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