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Tovetumab
🥰Excellent
Catalog No. T76764Cas No. 1243266-04-7
Alias MEDI-575
Tovetumab (MEDI-575) is a fully human monoclonal antibody that exhibits high selectivity for platelet-derived growth factor receptor alpha (PDGFRα). it functions by specifically inhibiting PDGFRα signal transduction pathways, and it is currently being utilized in clinical research for the treatment of aggressive malignancies including glioblastoma and non-small cell lung cancer (NSCLC).
Tovetumab
Tovetumab
🥰Excellent
Purity: 95%
Catalog No. T76764Alias MEDI-575Cas No. 1243266-04-7
Tovetumab (MEDI-575) is a fully human monoclonal antibody that exhibits high selectivity for platelet-derived growth factor receptor alpha (PDGFRα). it functions by specifically inhibiting PDGFRα signal transduction pathways, and it is currently being utilized in clinical research for the treatment of aggressive malignancies including glioblastoma and non-small cell lung cancer (NSCLC).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $298 | In Stock | |
| 5 mg | $788 | In Stock | |
| 10 mg | $1,230 | In Stock |
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Concentration:6.57 mg/mL
Purity:95%
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Product Introduction
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Chemical Properties
| Description | Tovetumab (MEDI-575) is a fully human monoclonal antibody that exhibits high selectivity for platelet-derived growth factor receptor alpha (PDGFRα). it functions by specifically inhibiting PDGFRα signal transduction pathways, and it is currently being utilized in clinical research for the treatment of aggressive malignancies including glioblastoma and non-small cell lung cancer (NSCLC). |
| In vitro | Methods: MG-63 cells were treated with Tovetumab (0.001-10 nM, 10 minutes), and the expression of related proteins was detected by Western blot. Results: Tovetumab was able to inhibit ligand-induced phosphorylation of human PDGFRα in MG-63 cells. [2] |
| In vivo | Methods: Tovetumab (0.6, 6.0, 60 mg/kg, intravenous injection) was administered to cynomolgus monkeys to observe its effects. Results: Tovetumab induced a more than 100-fold increase in circulating platelet-derived growth factor (PDGF-AA) levels in cynomolgus monkeys. [1] |
| Synonyms | MEDI-575 |
| Cas No. | 1243266-04-7 |
| Color | Transparent |
| Appearance | Liquid |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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