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TUG-424

Name: TUG-424
Brand: TargetMol
SKU: T17177
Price: 74 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17177Cas No. 1082058-99-8

Alias TUG424

TUG-424 significantly enhances glucose-stimulated insulin secretion at 100 nM. TUG-424 is a potent and selective free fatty acid receptor 1 agonist (EC50: 32 nM).

TUG-424

🥰Excellent

Purity: 98.94%

Catalog No. T17177Alias TUG424Cas No. 1082058-99-8

TUG-424 significantly enhances glucose-stimulated insulin secretion at 100 nM. TUG-424 is a potent and selective free fatty acid receptor 1 agonist (EC50: 32 nM).

Pack Size	Price	Availability
1 mg	$74	In Stock
5 mg	$162	In Stock
10 mg	$233	In Stock
25 mg	$389	In Stock
50 mg	$579	In Stock
100 mg	$829	In Stock
500 mg	$1,680	In Stock
1 mL x 10 mM (in DMSO)	$151	In Stock

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Purity:98.94%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	TUG-424 significantly enhances glucose-stimulated insulin secretion at 100 nM. TUG-424 is a potent and selective free fatty acid receptor 1 agonist (EC50: 32 nM).
Targets&IC50	FFA1/GPR40:（EC50）32 nM
In vitro	At equivalent glucose concentrations, TUG-424's roughly double enhancement of secretion in the context of 12 mM glucose parallels the effect triggered by palmitate. Increasing TUG-424 doses (100 nM to 10 µM) significantly boost glucose-stimulated insulin secretion, beginning notably at 100 nM and peaking at 3 µM. Additionally, TUG-424 slightly yet significantly diminishes basal insulin secretion at 2.8 mM glucose [1].
Synonyms	TUG424

Chemical Properties

Molecular Weight	264.32
Formula	C₁₈H₁₆O₂
Cas No.	1082058-99-8
Smiles	Cc1ccccc1C#Cc1ccc(CCC(O)=O)cc1
Relative Density.	1.17 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (189.16 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7833 mL	18.9165 mL	37.8329 mL	189.1646 mL
5 mM	0.7567 mL	3.7833 mL	7.5666 mL	37.8329 mL
10 mM	0.3783 mL	1.8916 mL	3.7833 mL	18.9165 mL
20 mM	0.1892 mL	0.9458 mL	1.8916 mL	9.4582 mL
50 mM	0.0757 mL	0.3783 mL	0.7567 mL	3.7833 mL
100 mM	0.0378 mL	0.1892 mL	0.3783 mL	1.8916 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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