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Apoptin-derived peptide
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Catalog No. TP2543Cas No. 2232156-31-7
Apoptin-derived peptide, an antitumor polypeptide, exhibits cytotoxic effects by promoting apoptosis and necrosis in gastric cancer (GC) cells through the modulation of the PI3K / AKT / ARNT signaling pathway. It also impedes both the invasion and migration of cancer cells by inhibiting the expression and phosphorylation of the p85 subunit of PI3K, subsequently suppressing the PI3K / AKT pathway critical to gastric cancer development [1].
Apoptin-derived peptide
Apoptin-derived peptide
😃Good
Catalog No. TP2543Cas No. 2232156-31-7
Apoptin-derived peptide, an antitumor polypeptide, exhibits cytotoxic effects by promoting apoptosis and necrosis in gastric cancer (GC) cells through the modulation of the PI3K / AKT / ARNT signaling pathway. It also impedes both the invasion and migration of cancer cells by inhibiting the expression and phosphorylation of the p85 subunit of PI3K, subsequently suppressing the PI3K / AKT pathway critical to gastric cancer development [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Apoptin-derived peptide, an antitumor polypeptide, exhibits cytotoxic effects by promoting apoptosis and necrosis in gastric cancer (GC) cells through the modulation of the PI3K / AKT / ARNT signaling pathway. It also impedes both the invasion and migration of cancer cells by inhibiting the expression and phosphorylation of the p85 subunit of PI3K, subsequently suppressing the PI3K / AKT pathway critical to gastric cancer development [1]. |
| In vitro | TP2543
T85926 T86293 T86717 TN7754 T9901A-054 T9901A-055 |
| Molecular Weight | 5177.33 |
| Formula | C223H417N89O50S |
| Cas No. | 2232156-31-7 |
| Sequence | Met-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Pro-Pro-Ser-Lys-Lys-Arg-Ile-Arg-Ile-Gly-Ile-Ala-Gly-Ile-Thr-Ile-Thr-Leu-Ser-Leu-Arg-Pro-Arg-Thr-Ala-Lys-Arg-Arg-Ile-Arg-Leu |
| Sequence Short | MGRKKRRQRRRKPPSKKRIRIGIAGITITLSLRPRTAKRRIRL |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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