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Azelaprag, (Cat. No. T14390, CAS. 2049980-18-7), also known as AMG 986,is a candidate active molecule as an apelin receptor agonist (EC50 = 0.32 nM). Azelaprag can be used for the treatment of neurological and cardiovascular diseases.

TargetMol—Star Molecules—BI-2493 (Cat. No. T72061,CAS. 2937344-16-4), Achieving “Pan-KRAS” Inhibition via Indirect Suppression

Trastuzumab (Cat. No. T9912, CAS. 180288-69-1), also known as trastuzumab, is a humanized monoclonal antibody that selectively binds to HER2 with high affinity. Trastuzumab exhibits antitumor activity and is used for the treatment of HER2-positive tumors. It can induce cell cycle arrest, mediate cytotoxicity, and inhibit DNA damage repair.

Discover MRTX1133, a potent and highly selective non-covalent KRAS G12D inhibitor. This article explores its molecular structure, unique binding mechanism, and exceptional anti-tumor efficacy in KRAS G12D-driven cancers like PDAC, along with its potential in combination therapy with Venetoclax to overcome drug resistance.

Explore RAS(ON) tri-complex inhibitors: Daraxonrasib, RMC-7977 & Zoldonrasib. Targeted solutions for active-state RAS mutations from TargetMol.

Explore Erastin, a potent ferroptosis activator targeting VDAC. Discover its mechanism in ROS-dependent cancer therapy research at TargetMol.

The mitochondrial apoptosis pathway is a tightly regulated biological process governed by a network of proteins, among which the Bcl-2 (B-cell lymphoma 2) family plays a central role. Acting as key regulators of mitochondrial outer membrane permeabilization (MOMP), Bcl-2 family proteins function as critical gatekeepers of cell fate.

Join us at AACR Annual Meeting 2026 (Booth 4407) and Drug Discovery Chemistry 2026 (Booth 307) in San Diego this April. Discover our latest solutions in cancer research and drug discovery.

Finerenone, an antifibrotic drug, has shown promising results in restoring fertility for women with premature ovarian insufficiency (POI). This breakthrough treatment targets ovarian stromal fibrosis, offering new hope for those struggling with POI-related infertility. Explore how finerenone and other FDA-approved antifibrotic drugs can open new doors in reproductive medicine.

Recent research published in the Journal of Virology highlights the important role of host molecular chaperones in viral infection. The study reveals that HSP90, a key cellular chaperone involved in protein folding and stabilization, is essential for the replication of Hepatitis A virus (HAV). Experimental evidence shows that disrupting HSP90 activity leads to a significant reduction in HAV replication. These findings suggest that host chaperone systems may play a critical role in the viral life cycle and could represent promising targets for antiviral research.