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20-Hydroxyeicosatetraenoic acid (hereinafter referred to as '20-HETE') is a long-chain fatty acid containing 20 carbon atoms.20-HETE is a metabolite of arachidonic acid (AA). AA, under the catalysis of the cytochrome P450 (CYP450) enzyme system, particularly the CYP4F2 enzyme, undergoes ω-hydroxylation to introduce a hydroxyl group at the C-20 position, thereby generating 20-HETE. The presence of this hydroxyl group distinguishes 20-HETE from other arachidonic acid metabolites and is crucial for its physiological and pathophysiological functions.

Cisplatin (CDDP), chemically known as cis-diamminedichloroplatinum(II), has the molecular formula PtCl₂(NH₃)₂. Cisplatin features a divalent platinum ion as the central ion, coordinated in a square planar configuration with four dsp² hybrid orbitals of platinum acting as empty orbitals. These orbitals accept lone pairs of electrons provided by two ammonia molecules and two chloride ions, forming a square planar coordination complex. In this molecular structure, the two ammonia molecules and the two chloride ions are positioned on the same side of the square plane, creating a cis configuration. This cis configuration is crucial for cisplatin's anticancer activity[1].

Puromycin dihydrochloride, catalog number T2219, also known as Puromycin 2HCl or CL13900 dihydrochloride, is the salt form of puromycin. Under identical experimental conditions, compounds in their salt form exhibit the same biological activity as their free base counterparts at the same molar concentration. However, Puromycin dihydrochloride typically has better water solubility and stability compared to the free base form.

3-Methyladenine (Catalog No. T1879), also known as 3-MA, 3-Methyladenine, and NSC 66389, is a PI3K inhibitor that exerts its autophagy-inhibiting effects by inhibiting PI3K. It plays an important role in the study of cell signaling and autophagy processes.

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Osimertinib is an orally available, third-generation EGFR inhibitor (EGFR-TKI) widely used for the treatment of non-small cell lung cancer (NSCLC) with EGFR mutations.

Venetoclax, Catalog number T2119, also known as GDC-0199, ABT 199, Venclexta, ABT-199, and ABT199. Venetoclax is a Bcl-2 inhibitor (Ki <0.01 nM) with high potency, selectivity, and oral activity. Venetoclax can induce autophagy and apoptosis.

MG-132, catalog number: T2154, also known as Z-LLL-al or Z-Leu-Leu-Leu-CHO, is a 26S proteasome inhibitor with an IC50 of 100 nM. It exhibits cell permeability and reversibility. MG-132 is capable of inducing apoptosis.

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Gastrin I, human, Catalog Number TP2030, also known as Gastrin I (human) or Gastrin 1, is an endogenous peptide produced in the stomach. It increases gastric pepsinogen and gastric acid secretion in rats through the CCK2 receptor.