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Sagittatoside A

Name: Sagittatoside A
Brand: TargetMol
SKU: TQ0163
Price: 393 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0163Cas No. 118525-35-2

Alias Icariin-A

Sagittatoside A (Icariin-A) is a flavonoid glycoside that can be extracted from Herba Epimedii. It induces the phosphorylation of serine 118 in the ERα, selectively activating estrogen response elements (ERE) and luciferase activity.

Sagittatoside A

🥰Excellent

Purity: 99.33%

Catalog No. TQ0163Alias Icariin-ACas No. 118525-35-2

Pack Size	Price	Availability
1 mg	$107	In Stock
5 mg	$263	In Stock
10 mg	Preferential	In Stock
25 mg	Preferential	In Stock
1 mL x 10 mM (in DMSO)	$393	In Stock

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Batch Information

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Purity:99.33%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Sagittatoside A (Icariin-A) is a flavonoid glycoside that can be extracted from Herba Epimedii. It induces the phosphorylation of serine 118 in the ERα, selectively activating estrogen response elements (ERE) and luciferase activity.
In vitro	In Sagittatoside A (24h) treatment, the expression of Bax, caspase-9 and caspase-3 in HepG2 cells increased in a concentration-dependent manner, while the expression of Bcl-2 decreased. [1]
In vivo	For 100 μM Sagittatoside A, the zebrafish mortality rate at 4 dpf was 16.7%. [2]
Synonyms	Icariin-A

Chemical Properties

Molecular Weight	676.66
Formula	C₃₃H₄₀O₁₅
Cas No.	118525-35-2
Smiles	O(C1=C(OC=2C(C1=O)=C(O)C=C(O)C2CC=C(C)C)C3=CC=C(OC)C=C3)[C@H]4[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@H](O)[C@@H](O)[C@H](C)O4
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (29.56 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.96 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4778 mL	7.3892 mL	14.7785 mL	73.8924 mL
5 mM	0.2956 mL	1.4778 mL	2.9557 mL	14.7785 mL
10 mM	0.1478 mL	0.7389 mL	1.4778 mL	7.3892 mL
20 mM	0.0739 mL	0.3695 mL	0.7389 mL	3.6946 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Sagittatoside AprogestogenReceptorprogestogen ReceptorEstrogenReceptorEstrogen ReceptorER