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Sagittatoside A

🥰Excellent
Catalog No. TQ0163Cas No. 118525-35-2
Alias Icariin-A

Sagittatoside A (Icariin-A) is a flavonoid glycoside that can be extracted from Herba Epimedii. It induces the phosphorylation of serine 118 in the ERα, selectively activating estrogen response elements (ERE) and luciferase activity.

Sagittatoside A

Sagittatoside A

🥰Excellent
Purity: 99.33%
Catalog No. TQ0163Alias Icariin-ACas No. 118525-35-2
Sagittatoside A (Icariin-A) is a flavonoid glycoside that can be extracted from Herba Epimedii. It induces the phosphorylation of serine 118 in the ERα, selectively activating estrogen response elements (ERE) and luciferase activity.
Pack SizePriceAvailabilityQuantity
1 mg$107In Stock
5 mg$263In Stock
10 mgPreferentialIn Stock
25 mgPreferentialIn Stock
1 mL x 10 mM (in DMSO)$393In Stock
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Purity:99.33%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
Sagittatoside A (Icariin-A) is a flavonoid glycoside that can be extracted from Herba Epimedii. It induces the phosphorylation of serine 118 in the ERα, selectively activating estrogen response elements (ERE) and luciferase activity.
In vitro
In Sagittatoside A (24h) treatment, the expression of Bax, caspase-9 and caspase-3 in HepG2 cells increased in a concentration-dependent manner, while the expression of Bcl-2 decreased. [1]
In vivo
For 100 μM Sagittatoside A, the zebrafish mortality rate at 4 dpf was 16.7%. [2]
SynonymsIcariin-A
Chemical Properties
Molecular Weight676.66
FormulaC33H40O15
Cas No.118525-35-2
SmilesO(C1=C(OC=2C(C1=O)=C(O)C=C(O)C2CC=C(C)C)C3=CC=C(OC)C=C3)[C@H]4[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@H](O)[C@@H](O)[C@H](C)O4
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 20 mg/mL (29.56 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.4778 mL7.3892 mL14.7785 mL73.8924 mL
5 mM0.2956 mL1.4778 mL2.9557 mL14.7785 mL
10 mM0.1478 mL0.7389 mL1.4778 mL7.3892 mL
20 mM0.0739 mL0.3695 mL0.7389 mL3.6946 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

Sagittatoside AprogestogenReceptorprogestogen ReceptorEstrogenReceptorEstrogen ReceptorER
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