Shopping Cart

Your shopping cart is currently empty

Diaplasinin

Name: Diaplasinin
Brand: TargetMol
SKU: T25915
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T25915Cas No. 481631-45-2

Alias PAI-749, PAI749

Diaplasinin (PAI-749) is a highly efficient inhibitor of plasminogen activator inhibitor-1 (PAI-1) with antithrombotic activity. It can be used in cardiovascular disease research.

Diaplasinin

Copy Product Info

😃Good

Purity: 99.02%

Catalog No. T25915Alias PAI-749, PAI749Cas No. 481631-45-2

Diaplasinin (PAI-749) is a highly efficient inhibitor of plasminogen activator inhibitor-1 (PAI-1) with antithrombotic activity. It can be used in cardiovascular disease research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$55	-	In Stock
5 mg	$129	-	In Stock
10 mg	$198	-	In Stock
25 mg	$455	-	In Stock
50 mg	$787	-	In Stock
100 mg	$1,280	-	In Stock
1 mL x 10 mM (in DMSO)	$143	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.02%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Diaplasinin (PAI-749) is a highly efficient inhibitor of plasminogen activator inhibitor-1 (PAI-1) with antithrombotic activity. It can be used in cardiovascular disease research.
Targets&IC50	uPA:87 nM, labeled PAI1:140 nM, TPA:157 nM, labeled PAI1:254 nM (Kd), PAI1:295 nM
In vitro	Diaplasinin is an inhibitor targeting plasminogen activator inhibitor 1 (PAI-1) with an IC50 of 295 nM.[1] Diaplasinin inhibits PAI-1 synthesis with high potency and selectivity, and maintains tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) activity in the presence of PAI-1, with IC50s of 157 nM and 87 nM, respectively. In addition, Diaplasinin exhibits an apparent Kd value of 254 nM and an IC50 value of 140 nM by quenching the fluorescence of fluorescently labeled PAI-1. [2]
Synonyms	PAI-749, PAI749

Chemical Properties

Molecular Weight	501.62
Formula	C₃₂H₃₁N₅O
Cas No.	481631-45-2
Smiles	N1=NNC(=N1)COC=2C=CC3=CC(=CC=C3C2)C4=C(C5=CC=CC=C5N4CC=6C=CC=CC6)CCCCC
Relative Density.	1.21g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (199.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9935 mL	9.9677 mL	19.9354 mL	99.6770 mL
5 mM	0.3987 mL	1.9935 mL	3.9871 mL	19.9354 mL
10 mM	0.1994 mL	0.9968 mL	1.9935 mL	9.9677 mL
20 mM	0.0997 mL	0.4984 mL	0.9968 mL	4.9839 mL
50 mM	0.0399 mL	0.1994 mL	0.3987 mL	1.9935 mL
100 mM	0.0199 mL	0.0997 mL	0.1994 mL	0.9968 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc