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L-Histidine

Name: L-Histidine
Brand: TargetMol
SKU: T2A2532
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2A2532Cas No. 71-00-1

Alias L-(-)-Histidine, histidine, Glyoxaline-5-alanine

L-Histidine (L-(-)-Histidine) is a semi-essential amino acid (children should obtain it from food) needed in humans for growth and tissue repair, L-Histidine is important for maintenance of myelin sheaths that protect nerve cells and is metabolized to the neurotransmitter histamine. Histamines play many roles in immunity, gastric secretion, and sexual functions. L-Histidine is also required for blood cell manufacture and protects tissues against damage caused by radiation and heavy metals.

L-Histidine

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Purity: 99.92%

Catalog No. T2A2532Alias L-(-)-Histidine, histidine, Glyoxaline-5-alanineCas No. 71-00-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$41	In Stock	In Stock
1 g	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.92%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

L-Histidine AI Summary

L-Histidine exhibits versatile bioactivity with notable activation of various carbonic anhydrase (CA) enzymes. It shows potent activation of human CA1 (KA = 0.03 µM), moderate activation of human CA2 (KA = 10.9 µM), and different degrees of activation for other CAs such as CA4, CA5A, CA5B, CA6, CA9, CA12, CA13, and CA14, with KA values ranging from 0.13 µM to 135.0 µM. Additionally, it demonstrates bioactivity in other biological processes, including reducing blood glucose levels in KKAy mice at a dose of 500 mg/kg over 4 days (MISS T/C = 0.8), and antioxidant activity by inhibiting the formation of hydroxyl radicals and reactive oxygen species (EC50 values of 100,000 nM and 6,000 nM, respectively). The compound also shows binding affinity (Kd = -7.31) to human histidine-binding proteins, inhibition of LAT1 with an IC50 of 200,000 nM, and pKa value of 6.2. These diverse bioactivities highlight its potential in modulating a variety of physiological processes and therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Synonyms

L-(-)-Histidine, histidine, Glyoxaline-5-alanine

Chemical Properties

Molecular Weight	155.15
Formula	C₆H₉N₃O₂
Cas No.	71-00-1
Smiles	N[C@@H](Cc1c[nH]cn1)C(O)=O
Relative Density.	1.423 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 29.7 mg/mL (191.43 mM), Sonication is recommended.

DMSO: Insoluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	6.4454 mL	32.2269 mL	64.4538 mL	322.2688 mL
5 mM	1.2891 mL	6.4454 mL	12.8908 mL	64.4538 mL
10 mM	0.6445 mL	3.2227 mL	6.4454 mL	32.2269 mL
20 mM	0.3223 mL	1.6113 mL	3.2227 mL	16.1134 mL
50 mM	0.1289 mL	0.6445 mL	1.2891 mL	6.4454 mL
100 mM	0.0645 mL	0.3223 mL	0.6445 mL	3.2227 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc