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Tyrosinase-IN-2

Name: Tyrosinase-IN-2
Brand: TargetMol
SKU: T60278
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60278Cas No. 180864-33-9

Tyrosinase-IN-2 (compound 67) is a potent inhibitor of tyrosinase, a copper-containing metalloenzyme crucial for the rate-limiting step in melanin biosynthesis and enzymatic browning processes. This compound shows promise for research into skin whitening agents and food preservatives [1].

Tyrosinase-IN-2

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Purity: 99.78%

Catalog No. T60278Cas No. 180864-33-9

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$39	In Stock	In Stock
25 mg	$82	In Stock	In Stock
50 mg	$133	In Stock	In Stock
100 mg	$215	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.78%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Tyrosinase-IN-2 AI Summary

Tyrosinase-IN-2 exhibits a wide range of bioactivities against several parasites and enzymes, showing significant potential as an anti-parasitic and multi-target therapeutic agent. It demonstrates anti-parasitic activity against Toxoplasma gondii, reducing the number of intracellular parasites in infected vero cells, with IC50 values of 1,500,000 nM and 500,000 nM for the infected cells and parasites, respectively. The compound also inhibits the trypomastigote and amastigote stages of Trypanosoma cruzi Y, with EC50 values of 1,430.0 nM and 3,230.0 nM, respectively, and selectivity indices of 26.2 and 11.6, indicating specificity towards the parasite over mammalian cells. Additionally, Tyrosinase-IN-2 shows various inhibitory activities: against jack bean urease (IC50 547.0 nM, Ki 497.0 nM), mushroom tyrosinase (IC50 1740.0 nM for diphenolase and 50.0 nM for monophenolase), and human ERG, along with inhibition of human microsomal CYP enzymes and recombinant human aurora B kinase. It also addresses multiple bacterial and viral targets, including inhibition of AmpC Beta-Lactamase, ROR gamma transcriptional activity, and Vaccinia Orthopoxvirus. The compound exhibits cytotoxicity against different human cell lines but also potentiates methotrexate-induced antitrypanosomal activity and displays permeability in PAMPA assays. This diverse bioactivity profile hints at its potential utility in treating multiple diseases, particularly parasitic infections..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	224.24
Formula	C₈H₈N₄O₂S
Cas No.	180864-33-9
Smiles	NC(=S)N\N=C\c1ccc(cc1)[N+]([O-])=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (222.98 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4595 mL	22.2975 mL	44.5951 mL	222.9754 mL
5 mM	0.8919 mL	4.4595 mL	8.9190 mL	44.5951 mL
10 mM	0.4460 mL	2.2298 mL	4.4595 mL	22.2975 mL
20 mM	0.2230 mL	1.1149 mL	2.2298 mL	11.1488 mL
50 mM	0.0892 mL	0.4460 mL	0.8919 mL	4.4595 mL
100 mM	0.0446 mL	0.2230 mL	0.4460 mL	2.2298 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc