Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Talotrexin (PT523), an analog of Aminopterin, is a nonpolyglutamatable classic antifolate that acts as a specific inhibitor of the reduced folate carrier (RFC). It selectively inhibits RFC transport, demonstrating antitumor activity by targeting dihydrofolate reductase (DHFR) to inhibit tumor growth [1] [2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Talotrexin (PT523), an analog of Aminopterin, is a nonpolyglutamatable classic antifolate that acts as a specific inhibitor of the reduced folate carrier (RFC). It selectively inhibits RFC transport, demonstrating antitumor activity by targeting dihydrofolate reductase (DHFR) to inhibit tumor growth [1] [2]. |
Synonyms | PT523 |
Molecular Weight | 573.56 |
Formula | C27H27N9O6 |
CAS No. | 113857-87-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Talotrexin 113857-87-7 PT523 PT 523 PT-523 inhibitor inhibit