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(Glu2)-TRH

Name: (Glu2)-TRH
Brand: TargetMol
SKU: T76493
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T76493 Copy Product Info

Purity: 99.99%

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(Glu2)-TRH is a metabolically stable analogue of Thyrotropin-releasing hormone (TRH) that functions as a negative modulator of the cholinergic effects of TRH in the mouse brain. (Glu2)-TRH significantly reduces TRH-induced extracellular acetylcholine release in the hippocampus and demonstrates resistance to metabolism by thyroliberinase. (Glu2)-TRH additionally exhibits neuroprotective, antidepressant, and anticonvulsant properties in the central nervous system. (Glu2)-TRH is therefore valuable for neuropharmacology, neurotransmitter regulation, and central nervous system signaling research.

Cas No. 85541-78-2

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Pack Size	Price	USA Stock	Global Stock
5 mg	$30	-	In Stock
10 mg	$48	-	In Stock
25 mg	$77	-	In Stock
50 mg	$113	-	In Stock
100 mg	$166	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.99%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description

In vivo

(Glu2)-TRH (1-100 μmol/kg; i.p.) dose-dependently attenuated thyrotropin-releasing hormone (TRH)-induced analeptic action in Swiss–Webster mice[1].
(Glu2)-TRH (1-100 μmol/kg; i.p.) afford a profound reversal of the TRH-evoked analeptic effect when doses to ≥2 mol/kg body weight in Swiss–Webster mice[1].

Chemical Properties

Molecular Weight	354.36
Formula	C₁₅H₂₂N₄O₆
Cas No.	85541-78-2
Smiles	C([C@@H](NC(=O)[C@@H]1CCC(=O)N1)CCC(O)=O)(=O)N2[C@H](C(N)=O)CCC2
Sequence	H-Pyr-Glu-Pro-NH₂
Sequence Short	XEP

Storage & Solubility Information

Storage

Keep away from moisture,Keep away from direct sunlight, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (225.76 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8220 mL	14.1099 mL	28.2199 mL	141.0994 mL
5 mM	0.5644 mL	2.8220 mL	5.6440 mL	28.2199 mL
10 mM	0.2822 mL	1.4110 mL	2.8220 mL	14.1099 mL
20 mM	0.1411 mL	0.7055 mL	1.4110 mL	7.0550 mL
50 mM	0.0564 mL	0.2822 mL	0.5644 mL	2.8220 mL
100 mM	0.0282 mL	0.1411 mL	0.2822 mL	1.4110 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: (Glu2)-TRH chemical structure | (Glu2)-TRH in vivo | (Glu2)-TRH formula | (Glu2)-TRH molecular weight