Shopping Cart

Your shopping cart is currently empty

8-Bromo-cAMP

Name: 8-Bromo-cAMP
Brand: TargetMol
SKU: T35424
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T35424Cas No. 23583-48-4

Alias 8-Bromo-Cyclic AMP, 8-Br-Camp

8-Bromo-cAMP is a cell-permeable cAMP analogue and activator of CAMP-dependent protein kinase A that induces cell death and reduces proliferation.

8-Bromo-cAMP

Copy Product Info

🥰Excellent

Purity: 97.30%

Catalog No. T35424Alias 8-Bromo-Cyclic AMP, 8-Br-CampCas No. 23583-48-4

8-Bromo-cAMP is a cell-permeable cAMP analogue and activator of CAMP-dependent protein kinase A that induces cell death and reduces proliferation.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	-
5 mg	$40	In Stock	-
10 mg	$56	In Stock	-
25 mg	$93	In Stock	-
50 mg	$151	In Stock	-
100 mg	$230	In Stock	-

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:97.30%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	8-Bromo-cAMP is a cell-permeable cAMP analogue and activator of CAMP-dependent protein kinase A that induces cell death and reduces proliferation.
In vitro	In primary rat renal tubular epithelial cells, 8-Bromo-cAMP (0.1 mM, 48 h) significantly increased both mRNA and protein levels of Na⁺-K⁺-ATPase α1 and β1 subunits, and promoted their membrane localization, suggesting enhancement of tubular ion transport via PKA signaling[1]. In NRK-52E rat renal proximal tubule epithelial cells, 8-Bromo-cAMP (10⁻⁶–10⁻³ mol/L, 48 h) significantly increased protein and mRNA levels of Na⁺-K⁺-ATPase α1 and β1 subunits (most prominently at 10⁻⁴ mol/L), and promoted their membrane localization, suggesting regulation via the cAMP/PKA signaling pathway[2].
In vivo	In renal denervation rat models, 8-Bromo-cAMP (0.5 mmol/L, perfused via the left renal artery at 0.05 mL/min for 60 min) significantly increased expression of Na⁺-K⁺-ATPase α1 and β1 subunits in the renal cortex, indicating its ability to enhance sodium pump activity and support renal ion transport in vivo[2].
Synonyms	8-Bromo-Cyclic AMP, 8-Br-Camp

Chemical Properties

Molecular Weight	408.1
Formula	C₁₀H₁₁BrN₅O₆P
Cas No.	23583-48-4
Smiles	BrC=1N(C=2C(N1)=C(N)N=CN2)[C@H]3[C@H](O)[C@]4([C@](O3)(COP(=O)(O)O4)[H])[H]

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

PBS (pH 7.2): 2 mg/mL (4.9 mM), Sonication is recommended.

1M NaOH: 83.33 mg/mL (204.19 mM)

Solution Preparation Table

PBS (pH 7.2)/1M NaOH

	1mg	5mg	10mg	50mg
1 mM	2.4504 mL	12.2519 mL	24.5038 mL	122.5190 mL

1M NaOH

	1mg	5mg	10mg	50mg
5 mM	0.4901 mL	2.4504 mL	4.9008 mL	24.5038 mL
10 mM	0.2450 mL	1.2252 mL	2.4504 mL	12.2519 mL
20 mM	0.1225 mL	0.6126 mL	1.2252 mL	6.1259 mL
50 mM	0.0490 mL	0.2450 mL	0.4901 mL	2.4504 mL
100 mM	0.0245 mL	0.1225 mL	0.2450 mL	1.2252 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc