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8-Bromo-cAMP is a cell-permeable cAMP analogue and activator of CAMP-dependent protein kinase A that induces cell death and reduces proliferation.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $42 | In Stock | |
10 mg | $59 | In Stock | |
25 mg | $98 | In Stock | |
50 mg | $159 | In Stock | |
100 mg | $242 | In Stock | |
200 mg | $397 | In Stock |
Description | 8-Bromo-cAMP is a cell-permeable cAMP analogue and activator of CAMP-dependent protein kinase A that induces cell death and reduces proliferation. |
In vitro | In primary rat renal tubular epithelial cells, 8-Bromo-cAMP (0.1 mM, 48 h) significantly increased both mRNA and protein levels of Na⁺-K⁺-ATPase α1 and β1 subunits, and promoted their membrane localization, suggesting enhancement of tubular ion transport via PKA signaling[1]. In NRK-52E rat renal proximal tubule epithelial cells, 8-Bromo-cAMP (10⁻⁶–10⁻³ mol/L, 48 h) significantly increased protein and mRNA levels of Na⁺-K⁺-ATPase α1 and β1 subunits (most prominently at 10⁻⁴ mol/L), and promoted their membrane localization, suggesting regulation via the cAMP/PKA signaling pathway[2]. |
In vivo | In renal denervation rat models, 8-Bromo-cAMP (0.5 mmol/L, perfused via the left renal artery at 0.05 mL/min for 60 min) significantly increased expression of Na⁺-K⁺-ATPase α1 and β1 subunits in the renal cortex, indicating its ability to enhance sodium pump activity and support renal ion transport in vivo[2]. |
Alias | 8-Bromo-Cyclic AMP, 8-Br-Camp |
Molecular Weight | 408.1 |
Formula | C10H11BrN5O6P |
Cas No. | 23583-48-4 |
Smiles | BrC=1N(C=2C(N1)=C(N)N=CN2)[C@H]3[C@H](O)[C@]4([C@](O3)(COP(=O)(O)O4)[H])[H] |
Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | PBS (pH 7.2): 2 mg/mL (4.9 mM), Sonication is recommended. 1 M NaOH: 80 mg/mL (196.03 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
PBS (pH 7.2)/1 M NaOH
1 M NaOH
|
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