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8-Bromo-cAMP

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Catalog No. T35424Cas No. 23583-48-4
Alias 8-Bromo-Cyclic AMP, 8-Br-Camp

8-Bromo-cAMP is a cell-permeable cAMP analogue and activator of CAMP-dependent protein kinase A that induces cell death and reduces proliferation.

8-Bromo-cAMP

8-Bromo-cAMP

🥰Excellent
Purity: 97.30%
Catalog No. T35424Alias 8-Bromo-Cyclic AMP, 8-Br-CampCas No. 23583-48-4
8-Bromo-cAMP is a cell-permeable cAMP analogue and activator of CAMP-dependent protein kinase A that induces cell death and reduces proliferation.
Pack SizePriceAvailabilityQuantity
5 mg$42In Stock
10 mg$59In Stock
25 mg$98In Stock
50 mg$159In Stock
100 mg$242In Stock
200 mg$397In Stock
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Purity:97.30%
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Product Introduction

Bioactivity
Description
8-Bromo-cAMP is a cell-permeable cAMP analogue and activator of CAMP-dependent protein kinase A that induces cell death and reduces proliferation.
In vitro
In primary rat renal tubular epithelial cells, 8-Bromo-cAMP (0.1 mM, 48 h) significantly increased both mRNA and protein levels of Na⁺-K⁺-ATPase α1 and β1 subunits, and promoted their membrane localization, suggesting enhancement of tubular ion transport via PKA signaling[1]. In NRK-52E rat renal proximal tubule epithelial cells, 8-Bromo-cAMP (10⁻⁶–10⁻³ mol/L, 48 h) significantly increased protein and mRNA levels of Na⁺-K⁺-ATPase α1 and β1 subunits (most prominently at 10⁻⁴ mol/L), and promoted their membrane localization, suggesting regulation via the cAMP/PKA signaling pathway[2].
In vivo
In renal denervation rat models, 8-Bromo-cAMP (0.5 mmol/L, perfused via the left renal artery at 0.05 mL/min for 60 min) significantly increased expression of Na⁺-K⁺-ATPase α1 and β1 subunits in the renal cortex, indicating its ability to enhance sodium pump activity and support renal ion transport in vivo[2].
Alias8-Bromo-Cyclic AMP, 8-Br-Camp
Chemical Properties
Molecular Weight408.1
FormulaC10H11BrN5O6P
Cas No.23583-48-4
SmilesBrC=1N(C=2C(N1)=C(N)N=CN2)[C@H]3[C@H](O)[C@]4([C@](O3)(COP(=O)(O)O4)[H])[H]
Storage & Solubility Information
Storagekeep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
PBS (pH 7.2): 2 mg/mL (4.9 mM), Sonication is recommended.
1 M NaOH: 80 mg/mL (196.03 mM), Sonication is recommended.
Solution Preparation Table
PBS (pH 7.2)/1 M NaOH
1mg5mg10mg50mg
1 mM2.4504 mL12.2519 mL24.5038 mL122.5190 mL
1 M NaOH
1mg5mg10mg50mg
5 mM0.4901 mL2.4504 mL4.9008 mL24.5038 mL
10 mM0.2450 mL1.2252 mL2.4504 mL12.2519 mL
20 mM0.1225 mL0.6126 mL1.2252 mL6.1259 mL
50 mM0.0490 mL0.2450 mL0.4901 mL2.4504 mL
100 mM0.0245 mL0.1225 mL0.2450 mL1.2252 mL

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