Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Ligand for E3 Ligase

 A required PROTAC component is a ligand binding to an E3 ubiquitin ligase, which is then joined to another ligand binding to a protein to be degraded via the ubiquitin–proteasome system. The advent of nonpeptidic small-molecule E3 ligase ligands, notably for von Hippel–Lindau (VHL) and cereblon (CRBN), revolutionized the field and ushered in the design of drug-like PROTACs with potent and selective degradation activity.During the past few years, these efforts have resulted in improved small-molecule-based PROTACs recruiting cereblon (CRBN), von Hippel–Lindau (VHL), and inhibitors of apoptosis proteins (IAPs). By leveraging these small-molecule E3 ligase ligands, the field has since extensively demonstrated that PROTACs can induce degradation of a variety of proteins, even at sub-nanomolar concentrations, and has validated their applications not only as biological tools but also as a new chemical modality for treatment of diseases in the clinic.

FilterHomePROTACLigand for E3 Ligase
HaloPROTAC3
T320431799506-07-2
HaloPROTAC3 (HaloPROTAC-3) is a conjugate of ligands for E3 and 16-atom-length linker and a degrader of HaloTag fusion proteins.
  • $112
In Stock
Size
QTY
Thalidomide
T021350-35-1
Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties.
  • $50
In Stock
Size
QTY
Pomalidomide-PEG4-C2-NH2
T179162225940-52-1
Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate incorporating the Pomalidomide-based cereblon ligand and 4-unit PEG linker.
  • $30
In Stock
Size
QTY
(S,R,S)-AHPC-PEG4-NH2
T15190L2010159-57-4
(S,R,S)-AHPC-PEG4-NH2 (VHL Ligand-Linker Conjugates 4) is a synthetic E3 ligase ligand-linker conjugate, consisting of a VHL ligand based on (S,R,S)-AHPC combined with a 4-unit PEG linker.
  • $38
In Stock
Size
QTY
(S,R,S)-AHPC hydrochloride
T42071448189-80-7
(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).
  • $33
In Stock
Size
QTY
VH-298
TQ01212097381-85-4
VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by PHD enzymes.
  • $39
In Stock
Size
QTY
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride
T188192376990-30-4
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride, incorporating an E3 ligase ligand and a linker, can be used as an immunomodulator for the treatment of cancer.
  • $42
In Stock
Size
QTY
Thalidomide-O-amido-C4-N3
T151892098488-36-7
Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) is an E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker.
  • $51
In Stock
Size
QTY
(S,R,S)-AHPC-PEG1-N3
T179202101200-09-1
(S,R,S)-AHPC-PEG1-N3 (E3 ligase Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate that includes the (S,R,S)-AHPC-based VHL ligand and a 1-unit PEG linker used in PROTAC technology.
  • $33
In Stock
Size
QTY
Pomalidomide-PEG4-Ph-NH2
T77561818885-63-0
Pomalidomide-PEG4-Ph-NH2 is a synthetic E3 ligase ligand-linker conjugate that integrates a Pomalidomide-based cereblon ligand with a 4-unit PEG linker.
  • $30
In Stock
Size
QTY
(S,R,S)-AHPC-C4-NH2 hydrochloride
T186402245697-83-8
(S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) is a synthesized E3 ligase ligand-linker conjugate comprising the (S,R,S)-AHPC-based VHL ligand and a linker.
  • $32
In Stock
Size
QTY
(S,S,S)-AHPC hydrochloride
T138772115897-23-7
(S,S,S)-AHPC hydrochloride ((S,S,S)-VH032-NH2 hydrochloride) is a VHL amino building block and ligand used as a negative control for (S,R,S)-AHPC. It is based on VH032 and is employed in the recruitment of the VHL protein.
  • $38
In Stock
Size
QTY
Thalidomide-propargyl
T188312098487-39-7
Thalidomide-propargyl, a Thalidomide-derived Cereblon ligand, facilitates the recruitment of Cereblon. It can be attached to the protein ligand via a linker, producing IMiD-containing PROTACs.
  • $46
In Stock
Size
QTY
TargetMol | Inhibitor Sale
VL285
T53341448188-57-5
VL285 is a potent VHL ligand, degrading HaloTag7 fusion proteins.
  • $41
In Stock
Size
QTY
TargetMol | Inhibitor Sale
SIAIS178
T129072376047-73-1
SIAIS178 is a selective PROTAC degrader targeting BCR-ABL with an IC50 of 24 nM. It degrades BCR-ABL protein by recruiting the VHL E3 ubiquitin ligase, inhibiting leukaemia cell growth in vitro and causing regression of K562 xenograft tumours.
  • $163
In Stock
Size
QTY
MV-1-NH-Me
T186132095244-62-3
MV-1-NH-Me, an MV-1-derived IAP ligand, connects to an ABL inhibitor through a linker, resulting in the formation of SNIPER[1].
  • Inquiry Price
Size
QTY
(S,R,S)-AHPC-propargyl
T138762098799-78-9
(S,R,S)-AHPC-propargyl, a VHL ligand, is utilized in click reactions for PROTACs.
  • $83
5 days
Size
QTY
Thalidomide-5-(C6-amine)
T2063981950635-17-2
Thalidomide-5-(C6-amine) is a component of a PROTAC, featuring an E3 ligase ligand substituted with a terminal amine group. This amine group can react with NHS ester groups or carboxylic acids in the presence of either EDC or HATU.
  • Inquiry Price
10-14 weeks
Size
QTY
Thalidomide-1-Me,5-F
T2063512230957-36-3
Thalidomide-1-Me,5-F is a fluorinated E3 ligase activator utilized for further derivatization through SNAr (nucleophilic aromatic substitution).
  • Inquiry Price
10-14 weeks
Size
QTY
Thalidomide-1-Me-5-NH2
T2065821468761-60-5
Thalidomide-1-Me-5-NH2 is an aminated analog of Thalidomide. This type of E3 ligase activator can be utilized in the design of PROTAC molecules through derivatization on its amine group.
  • Inquiry Price
10-14 weeks
Size
QTY
3-Azathalidomide
T20656931804-66-7
3-Azathalidomide is a thalidomide analogue that can be utilized in PROTAC research.
  • Inquiry Price
10-14 weeks
Size
QTY
Tetrafluoro-thalidomide
T206900179033-21-7
Tetrafluoro-thalidomide is a fluorinated analog of thalidomide. It acts as an activator of E3 ligase enzymes, facilitating the ubiquitination of proteins for subsequent proteolysis. The structure of tetrafluoro-thalidomide can be further derivatized through fluorine substitution.
  • Inquiry Price
10-14 weeks
Size
QTY
MS1262
T2069393070323-06-4
MS1262 is a ligand for the E3 ubiquitin ligase of the compound MS1262-C3-amide-C10-amine. It can be used in the synthesis of PROTAC.
  • Inquiry Price
10-14 weeks
Size
QTY
E3 ligase Ligand 64
T2072792760850-50-6
E3ligaseLigand 64 is a ligand for E3 ligase, useful in the synthesis of RP03707.
  • Inquiry Price
10-14 weeks
Size
QTY