Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CAY10787 is an oxysterol and a negative allosteric modulator of GABAAreceptors.1,2It reduces GABA-induced currents in HEK cells expressing α1β1γ2or α4β3γ2subunit-containing GABAAreceptors (IC50s = 1.5 and 1 μM, respectively).2CAY10787 (500 nM) reduces GABA-induced depolarization of peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse dorsal root ganglion (DRG) neurons.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 275.00 | |
5 mg | 35 days | $ 1,150.00 | |
10 mg | 35 days | $ 2,160.00 |
Description | CAY10787 is an oxysterol and a negative allosteric modulator of GABAAreceptors.1,2It reduces GABA-induced currents in HEK cells expressing α1β1γ2or α4β3γ2subunit-containing GABAAreceptors (IC50s = 1.5 and 1 μM, respectively).2CAY10787 (500 nM) reduces GABA-induced depolarization of peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse dorsal root ganglion (DRG) neurons. |
In vivo | In vivo, CAY10787 (2, 10, and 50 mg/kg) increases latency to nocifensive behaviors in the hot plate test in mice. |
Molecular Weight | 382.632 |
Formula | C27H42O |
CAS No. | 567-72-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Chloroform: 10 mg/mL
You can also refer to dose conversion for different animals. More
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CAY10787 567-72-6 CAY 10787 CAY-10787 inhibitor inhibit